1,2,3,4-tetrahydroanthracen-9-amine | 1348473-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,2,3,4-tetrahydroanthracen-9-amine
• 英文别名: 1,2,3,4-Tetrahydro-9-anthracenamine
• CAS: 1348473-64-2
• 化学式: C₁₄H₁₅N
• mdl: MFCD25953469
• 分子量: 197.28
• InChiKey: XLMJNBAZHRTJED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tetrahydroanthracen-9-amine 在 rhodium contaminated with carbon 、 三氟乙酸 作用下， 以 三氟乙酸 为溶剂， 反应 2.0h， 以100%的产率得到1,1',2,2',3,3',4,4'-octahydro-9,9'-bianthracen-10,10'-diamine
  参考文献：
  名称：

  Aerobic Oxidative Homocoupling of Aryl Amines Using Heterogeneous Rhodium Catalysts

  摘要：

  The first heterogeneous catalyzed oxidative coupling of aryl amines is reported. Aryl amines were dimerized at room temperature under air using a heterogeneous Rh/C catalyst in the presence of acids. By choosing a suitable acidic solvent, biaryl compounds and carbazoles were selectively prepared in good yields. This reaction is operationally simple and provides an efficient synthetic methodology for the preparation of biaryl diamines via oxidative C-H activation.

  DOI：

  10.1021/ol502197p
• 作为产物：
  描述：

  9-硝基蒽 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 20.0h， 以73%的产率得到1,2,3,4-tetrahydroanthracen-9-amine
  参考文献：
  名称：

  Aerobic Oxidative Homocoupling of Aryl Amines Using Heterogeneous Rhodium Catalysts

  摘要：

  The first heterogeneous catalyzed oxidative coupling of aryl amines is reported. Aryl amines were dimerized at room temperature under air using a heterogeneous Rh/C catalyst in the presence of acids. By choosing a suitable acidic solvent, biaryl compounds and carbazoles were selectively prepared in good yields. This reaction is operationally simple and provides an efficient synthetic methodology for the preparation of biaryl diamines via oxidative C-H activation.

  DOI：

  10.1021/ol502197p

文献信息

• AGENT EXHIBITING THE PROPERTIES OF A COGNITIVE FUNCTION PROMOTER (EMBODIMENTS)
  申请人：Obschestvo S Ogranichennoi Otvetstvennostju "Unikorm"

  公开号：EP2564851A2

  公开（公告）日：2013-03-06

  The present invention relates to the field of chemical-pharmaceutical industry and medicine. An agent, exhibiting the properties of a cognitive function promoter, was selected from 1,3-dimethyl-5-[(4-pyridylamino)methylene]barbituric acid and 4-amino-1-(3-nitro-2-oxo-1-pheny-1,2-dihydro-1,6-naphthyridin-5-yl)pyridinium chloride. The compounds, that are proposed as agents, exhibit potent biological activity.

  本发明涉及化学制药工业和医学领域。从 1,3-二甲基-5-[(4-吡啶氨基)亚甲基]巴比妥酸和 4-氨基-1-(3-硝基-2-氧代-1-苯基-1,2-二氢-1,6-萘啶-5-基)氯化吡啶中选出了一种具有认知功能促进剂特性的药剂。这些拟用作制剂的化合物具有很强的生物活性。
• Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, and in vitro inhibition of amyloid β1–42 peptide aggregation, acetylcholinesterase and carbonic anhydrase-II
  作者：Ayesha Tahir、Bushra Mobeen、Fahad Hussain、Abdul Sadiq、Umer Rashid

  DOI：10.1039/d4ra01536c

  日期：——

  state, which is a specific conformation of proteins, offers valuable information about both functional protein structures and the pathological assemblies associated with various diseases. One of the major hallmarks of Alzheimer's disease includes primarily the extracellular build-up of a peptide known as amyloid-β, which has a sequence consisting of 39 to 42 amino acid residues, and the formation of intracellular

  淀粉样蛋白状态是蛋白质的一种特定构象，它提供了有关功能性蛋白质结构和与各种疾病相关的病理组装的有价值的信息。阿尔茨海默病的主要特征之一主要包括一种称为淀粉样蛋白-β（其序列由 39 至 42 个氨基酸残基组成）的肽在细胞外的积聚，以及主要由过度磷酸化 tau 蛋白组成的细胞内神经原纤维缠结的形成。有望减少 Aβ 产生、防止 Aβ 聚集和促进 Aβ 清除的药物是治疗 AD 的有前景的方法。目前的工作重点是鉴定能够平衡多个靶点的温和生物活性的化合物，而不是寻找具有高效力的单一靶点化合物。我们合成了孕烯醇酮衍生物，并评估了它们抑制 eeAChE/eqBChE、hCA-II 和自介导 Aβ 1-42肽聚集的潜力。我们合成的衍生物23和25-27表现出对所有测试的大分子靶标的伴随抑制。在 PAMPA 测定中发现所有活性化合物都是 BBB 渗透剂。此外，在神经母细胞瘤 SH-SY5Y 细胞的 MTT
• CN116354990
  申请人：——

  公开号：——

  公开（公告）日：——