2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetamide
• 化学式: C₈H₆ClF₃N₂O
• mdl: MFCD01814799
• 分子量: 238.597
• InChiKey: KUYHPTSOTBSQCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetamide 、 {1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-oxo-acetic acid methyl ester 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3

  摘要：

  A novel series of acyclic 3-(7-azaindolyl)-4-(aryl/heteroaryl)maleimides was synthesized and evaluated for activity against GSK-3beta and selectivity versus PKC-betaII, as well as a broad panel of protein kinases. Compounds 14 and 17c potently inhibited GSK-3beta (IC50=7 and 26nM, respectively) and exhibited excellent selectivity over PKC-betaII (325 and >385-fold, respectively). Compound 17c was also highly selective against 68 other protein kinases. In a cell-based functional assay, both 14 and 17c effectively increased glycogen synthase activity by inhibiting GSK-3beta. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.090

文献信息

• New fungicidal compounds
  申请人：Bayer CropScience SA

  公开号：EP1449841A1

  公开（公告）日：2004-08-25

  Compound of general formula (I): Process for preparing this compound. Novel intermediate of general formula (E): for the preparation of compound of general formula (I) Fungicidal composition comprising a compound of general formula (I). Method for treating plants by applying a compound of general formula (I) or a composition comprising it.

  通式（I）的化合物组合物： 制备该化合物的方法。 通式（E）的新型中间体： 用于制备通式（I）的化合物。 包括通式（I）化合物的杀真菌组合物。 通过应用通式（I）的化合物或包含它的组合物来治疗植物的方法。
• Pyridine derivatives as fungicidal compounds
  申请人：Mansfield James Darren

  公开号：US20060052366A1

  公开（公告）日：2006-03-09

  Compound of general formula (I): Process for preparing thus compound. Novel intermediate of general formula (E): for the preparation of compound of general formula (I) Fungicidal composition comprising a compound of general formula (I). Method for treating plants by applying a compound of general formula (I) or a composition comprising it.

  通式（I）的化合物的制备方法。通式（E）的新中间体，用于制备通式（I）的化合物。包含通式（I）化合物的杀菌组合物。通过应用通式（I）化合物或包含它的组合物来治疗植物的方法。
• US7754741B2
  申请人：——

  公开号：US7754741B2

  公开（公告）日：2010-07-13