2-[1-(4-chlorophenyl)-cyclobutyl]acetonitrile | 84467-22-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[1-(4-chlorophenyl)-cyclobutyl]acetonitrile
• 英文别名: 2-[1-(4-Chlorophenyl)cyclobutyl]acetonitrile
• CAS: 84467-22-1
• 化学式: C₁₂H₁₂ClN
• 分子量: 205.687
• InChiKey: OEYNIBRJHDKARY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-[1-(4-chlorophenyl)-cyclobutyl]acetonitrile 生成 2-(1-(4-chlorophenyl)cyclobutyl)acetic acid
  参考文献：
  名称：

  Arylcyclobutylalkylamines and anti-depression composition and methods

  摘要：

  式I的化合物 ##STR1## 其中R.sub.1为H或C.sub.1-3烷基；R.sub.2为H或C.sub.1-3烷基；R.sub.3和/或R.sub.4为H、C.sub.1-3烷基、C.sub.3-6烯基、C.sub.3-6炔基、C.sub.3-7环烷基或R.sub.3和R.sub.4与氮原子一起形成杂环环系；R.sub.5和/或R.sub.6为H、卤素、CF.sub.3或C.sub.1-3烷基（但R.sub.5和R.sub.6不能同时为H或甲基），或R.sub.5和R.sub.6与它们附着的碳原子一起形成第二个苯环，R.sub.7和/或R.sub.8为H或C.sub.1-3烷基，在治疗抑郁症方面具有治疗活性。还公开了制备式I化合物的药物组合物和过程。

  公开号：

  US04443449A1
• 作为产物：
  描述：

  对甲苯磺酰氯 、 1-[1-(4-Chlorophenyl)cyclobutyl]methyl p-toluene sulphonate 在 盐酸 作用下， 以 吡啶 、 二甲基亚砜 为溶剂， 生成 2-[1-(4-chlorophenyl)-cyclobutyl]acetonitrile
  参考文献：
  名称：

  Therapeutic agents

  摘要：

  化学式I的化合物##STR1##中，其中R.sub.1为C.sub.1-6烷基，C.sub.2-6烯基，C.sub.2-6炔基，C.sub.3-7环烷基，环烷基烷基或可选择取代的苯基；R.sub.2为H或C.sub.1-3烷基；R.sub.3和/或R.sub.4为H，甲酰基，C.sub.1-3烷基，C.sub.3-6烯基，C.sub.3-6炔基，C.sub.3-7环烷基或R.sub.3和R.sub.4与氮原子一起形成杂环环系统；R.sub.5和/或R.sub.6为H，卤素，CF.sub.3，C.sub.1-3烷基，C.sub.1-3烷氧基，C.sub.1-3烷硫基或R.sub.5和R.sub.6与它们连接的碳原子一起形成第二苯环，表现出治疗抑郁症的活性。公开了制备化学式I化合物的药物组合物和方法。

  公开号：

  US04522828A1

文献信息

• SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOALKYLMETHYLAMINES
  申请人：Bhat Laxminarayan

  公开号：US20080139663A1

  公开（公告）日：2008-06-12

  The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.

  本发明提供了新型的环烷甲基胺类似物，以及制备环烷甲基胺类似物的方法。本发明还提供了使用环烷甲基胺类似物的方法和环烷甲基胺类似物的组合物。本发明化合物的制药组合物可以优势地用于治疗和/或预防肥胖和肥胖相关的合并症。
• NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
  申请人：Pesyan Amir

  公开号：US20110046128A1

  公开（公告）日：2011-02-24

  A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, these/such compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.

  本文介绍了一系列新型化合物，具有抗惊厥、化学对抗剂和镇痛活性。这些药物活性化合物也可能在治疗其他中枢神经系统（“CNS”）疾病和障碍方面发挥作用，如焦虑、抑郁、失眠、偏头痛、精神分裂症、帕金森病、痉挛、阿尔茨海默病和双相情感障碍。此外，这些化合物还可以作为镇痛剂（例如，用于慢性或神经性疼痛的治疗）和作为神经保护剂，有助于治疗中风、慢性神经退行性疾病（如阿尔茨海默病和亨廷顿病）以及创伤性脑和/或脊髓损伤。此外，这些化合物还可以用于治疗癫痫持续状态和/或作为化学对抗剂。
• Methods of Using Cycloalkylmethylamines
  申请人：Bhat Laxminarayan

  公开号：US20110263704A1

  公开（公告）日：2011-10-27

  The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.

  本发明提供了新型环烷基甲胺类似物和制备环烷基甲胺类似物的方法。本发明还提供了使用环烷基甲胺类似物和环烷基甲胺类似物组成物的方法。本发明的化合物制药组合物可以优势地用于治疗和/或预防肥胖和肥胖相关的共病症。
• Cycloalkylmethylamines
  申请人：Bhat Laxminarayan

  公开号：US20110263888A1

  公开（公告）日：2011-10-27

  The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.

  本发明提供了新型环烷基甲基胺类似物，以及制备环烷基甲基胺类似物的方法。本发明还提供了使用环烷基甲基胺类似物的方法和环烷基甲基胺类似物的组成物。本发明化合物的制药组合物可以优势地用于治疗和/或预防肥胖及其相关的共病症。
• Compounds advantageous in the treatment of central nervous system diseases and disorders
  申请人：AurimMed Pharma, Inc.

  公开号：US10793515B2

  公开（公告）日：2020-10-06

  A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.

  一系列新型酰胺具有广泛的药物活性。本文所述化合物可作为抗惊厥剂、化学对策和镇痛剂。这些化合物还具有神经保护/神经恢复作用，并对脊髓性肌肉萎缩具有活性。这类药物活性化合物可用于治疗中枢神经系统（CNS）疾病和失调，如焦虑症、抑郁症、失眠症、偏头痛、精神分裂症、神经退行性疾病（如帕金森氏病、阿尔茨海默氏症、渐冻人症和亨廷顿氏病）、痉挛症和躁狂症。此外，这类化合物还可作为镇痛剂（如治疗慢性疼痛或神经性疼痛）和神经保护剂用于治疗中风和/或创伤性脑损伤和/或脊髓损伤。