naphtho<2,3-f>quinoxaline-7,12-dione | 54490-26-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: naphtho<2,3-f>quinoxaline-7,12-dione
• 英文别名: NSC745887；Naphtho<2,3-f>chinoxalin-7,12-dion；naphtho[2,3-f]quinoxaline-7,12-dione；7,12-dioxo-7,12-dihydroanthra[1,2-b]pyrazine；naphtho[3,2-f]quinoxaline-7,12-dione
• CAS: 54490-26-5
• 化学式: C₁₆H₈N₂O₂
• 分子量: 260.252
• InChiKey: DGLSEJAACVWJNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  naphtho<2,3-f>quinoxaline-7,12-dione 以33%的产率得到
  参考文献：
  名称：

  AKIHIRO OHTA; KAZUKO HASEGAWA; KATSUYO AMANO; CIHARU MORI; AKIKO OHSAWA; +, CHEM. AND PHARM. BULL., 1979, 27, NO 11 2596-2601

  摘要：

  DOI：
• 作为产物：
  描述：

  草酸醛 、 1,2-二氨基蒽醌 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以23%的产率得到naphtho<2,3-f>quinoxaline-7,12-dione
  参考文献：
  名称：

  一系列1,2-杂芳基蒽醌和蒽[1,2 - d ]咪唑-6,11-二酮同系物的合成，细胞毒性和人类端粒酶抑制活性

  摘要：

  使用各种合成途径，通过酰化，环化，缩合和分子内杂环化，制备了一系列具有不同侧链的1,2-杂退火蒽醌和蒽[1,2 - d ]咪唑-6,11-二酮四环类似物。引入了包含烷基和芳基，芳族和杂环，线性和环状，极性和非极性以及碱性和酸性残基的四环体系。他们评估了它们对端粒酶活性，hTERT表达，细胞增殖以及对NCI 60细胞株人类肿瘤筛查的体外细胞毒性的影响。化合物4，11，12，14，15，16，17，19，20，23，25，和26是由NCI选择用于一个剂量筛选程序和进一步的研究4，23和25，其中曲线跨越这些线代表的内插值，以使50％生长抑制（GI 50），总生长抑制（TGI）和50％细胞杀伤率（LC 50）， 分别。进一步的研究未发现任何显示出对端粒酶抑制活性和hTERT抑制能力有效且显着的化合物。在NCI的筛选中对这些化合物进行的对比测试显示出不同的效力水平和不同的细胞毒性作用，显然与核心环

  DOI：

  10.1016/j.bmc.2009.09.033

文献信息

• HETEROANNELATED ANTHRAQUINONE DERIVATIVES AND THE SYNTHESIS METHOD THEREOF
  申请人：HUANG Hsu-Shan

  公开号：US20090253707A1

  公开（公告）日：2009-10-08

  A heteroannelated anthraquinone derivative compound is provided. The heteroannelated anthraquinone derivative compound is represented by a formula (I): wherein R 1 is a substituent being one selected from a group consisting of i) a first substituent being one selected from a group consisting of a hydryl group, an amino group, a nitro group, a hydroxyl group and a cyan group, ii) a second substituent being one selected from a group consisting of (CH 2 ) n X, a straight (CH 2 ) n alkyl group, a (CH 2 ) n alkoxyl group, a branched (CH 2 ) n alkyl group, a C 3 ˜C 12 nephthenic group, and a C 3 ˜C 12 cyclic alkoxyl group, wherein 1=n=12, and X is a halogen, iii) a third substituent being one selected from a group consisting of a straight C 1 ˜C 8 alkyl group with a double-bond, a C 1 ˜C 8 alkoxyl group with a double-bond, a branched C 1 ˜C 8 alkyl group with a double-bond and a C 3 ˜C 8 nephthenic group with a double-bond, and iv) a fourth substituent of a C 5 ˜C 12 heterocyclic group.

  提供一个杂环化的蒽醌衍生物化合物，所述杂环化的蒽醌衍生物化合物由公式(I)表示： 其中R1是选自以下组中的取代基：i)第一取代基，选自包含羟基、氨基、硝基、羟基和氰基的组，ii)第二取代基，选自包含(CH2)nX、直链(CH2)n烷基、(CH2)n烷氧基、支链(CH2)n烷基、C3˜C12的环烷基和C3˜C12的环烷氧基的组，其中1≤n≤12，X是卤素，iii)第三取代基，选自包含直链C1˜C8的双键烷基、C1˜C8的双键烷氧基、支链C1˜C8的双键烷基和C3˜C8的双键环烷基的组，以及iv)第四取代基为C5˜C12的杂环基团。
• METHOD FOR INHIBITING GROWTH OF CANCER CELLS AND CELL TELOMERE AND DISEASES OF CELL PROLIFERATION BY USING HETEROANNELATED ANTHRAQUINONE DERIVATIVE COMPOUNDS
  申请人：HUANG Hsu-Shan

  公开号：US20100249143A1

  公开（公告）日：2010-09-30

  A heteroannelated anthraquinone derivative compound is provided. The heteroannelated anthraquinone derivative compound is represented by a formula (I): wherein R 1 is a substituent being one selected from a group consisting of i) a first substituent being one selected from a group consisting of a hydryl group, an amino group, a nitro group, a hydroxyl group and a cyan group, ii) a second substituent being one selected from a group consisting of (CH 2 ) n X, a straight (CH 2 ) n alkyl group, a (CH 2 ) n alkoxyl group, a branched (CH 2 ) n alkyl group, a C 3 ˜C 12 nephthenic group, and a C 3 ˜C 12 cyclic alkoxyl group, wherein 1≦n≦12, and X is a halogen, iii) a third substituent being one selected from a group consisting of a straight C 1 ˜C 8 alkyl group with a double-bond, a C 1 ˜C 8 alkoxyl group with a double-bond, a branched C 1 ˜C 8 alkyl group with a double-bond and a C 3 ˜C 8 nephthenic group with a double-bond, and iv) a fourth substituent of a C 5 ˜C 12 heterocyclic group.

  提供了一种杂环螺环酮衍生物化合物。该杂环螺环酮衍生物化合物由以下式子（I）表示： 其中R1是一个取代基，选自以下一组中的一种：i）第一取代基选自羟基、氨基、硝基、羟基和氰基组成的群体中的一种、ii）第二取代基选自（CH2）nX、直链（CH2）n烷基、（CH2）n烷氧基、支链（CH2）n烷基、C3˜C12环烷氧基和C3˜C12环烷氧基，其中1≦n≦12，X是卤素、iii）第三取代基选自带双键的直链C1˜C8烷基、带双键的C1˜C8烷氧基、带双键的支链C1˜C8烷基和带双键的C3˜C8环烷基、以及iv）C5˜C12杂环基的第四取代基。
• Process for the delignification of lignocellulosic material and products thereof
  申请人：C.I.L. Inc.

  公开号：EP0010451A1

  公开（公告）日：1980-04-30

  There is disclosed a process for the delignification of lignocellulosic material by treatment with an alkaline liquor in the presence of a cyclic keto compound such as anthraquinone. The lignocellulosic material in subdivided form is first impregnated with the alkaline liquor containing a suitable amount of the cyclic keto compound whereafter any excess liquor is drained. The impregnated material is then cooked by heating. The delignified products are suitable for the manufacture of paper.

  本发明公开了一种木质纤维素材料的脱木素工艺，即在蒽醌等环酮化合物存在的情况下，用碱性液处理木质纤维素材料。首先用含有适量环酮化合物的碱性液体浸渍细分的木质纤维素材料，然后排出多余的液体。然后将浸渍过的材料加热蒸煮。脱木素产品适用于造纸。
• Additive composition and process for reducing anthraquinone requirements in pulping of lignocellulosic material
  申请人：WESTVACO CORPORATION

  公开号：EP0864689A2

  公开（公告）日：1998-09-16

  An improved preliminary aid composition and process for delignification of lignocellulosic raw material, such as wood chips, for the production of cellulose pulps for use in the manufacture of paper or paperboard are disclosed wherein the wood chips are treated in a closed reaction vessel with an alkaline pulping liquor with an amount of a cyclic keto compound, such as anthraquinone, included therein for achievement of a determined pulp yield, wherein the improvement comprises a reduction in the amount of anthraquinone required to achieve said yield by the addition to said alkaline pulping liquor, in addition to a reduced amount of the anthraquinone, a surfactant mixture comprising at least one alkyl alcohol alkoxylate and at least one polyoxyalkylene glycol ether of an ester of an acid selected from the group consisting of ricinoleic acid and 12-hydroxystearic acid.

  本发明公开了一种用于木质纤维素原料（如木片）脱木素以生产用于制造纸或纸板的纤维素浆的改进型初步助剂组合物和工艺，其中木片在密闭反应容器中与含有一定量环酮化合物（如蒽醌）的碱性制浆液一起处理，以达到确定的纸浆得率、其中的改进包括，除了减少蒽醌的用量外，还在所述碱性制浆液中加入一种表面活性剂混合物，以减少达到所述产浆量所需的蒽醌用量，该表面活性剂混合物包括至少一种烷基醇烷氧基化物和至少一种选自蓖麻油酸和 12-羟基硬脂酸的酸酯的聚氧亚烷基乙二醇醚。
• Extended performance bird repellent exterior coating
  申请人：Arkion Life Sciences

  公开号：US10400138B2

  公开（公告）日：2019-09-03

  The invention relates to the use of a persistent, weatherable blend of a bird repellent and a paint coating composition on exterior surfaces such as wood or building materials, to deter birds from damaging such wood or building material. The bird repellent blend has improved weatherability while retaining the effectiveness of the bird repellent.

  本发明涉及在木材或建筑材料等外表面使用一种持久性、耐候性的驱鸟剂与涂料涂层组合物的混合物，以阻止鸟类破坏这些木材或建筑材料。这种驱鸟剂混合物具有更好的耐候性，同时保留了驱鸟剂的功效。