(2S)-1-tert-butylazetidin-1-ium-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-1-tert-butylazetidin-1-ium-2-carboxylate
• 化学式: C8H15NO2
• 分子量: 157.21
• InChiKey: DGBAPZLVXNOENB-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds Useful as Immunomodulators
  申请人：Bristol-Myers Squibb Company

  公开号：US20150291549A1

  公开（公告）日：2015-10-15

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开涉及一般用作免疫调节剂的化合物。提供的是包含这些化合物的化合物、组合物以及它们的使用方法。本公开还涉及包含至少一种根据本公开的化合物的药物组合物，用于治疗各种疾病，包括癌症和传染病。
• Process for producing optically active N-substituted azetidine-2-carboxylic acid compound
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0974670A2

  公开（公告）日：2000-01-26

  There is provided a process for producing an optically active N-substituted azetidine-2-carboxylic acid compound represented by the formula (2): by contacting a corresponding N-substituted azetidine-2-carboxylic acid ester of formula (2) with an enzyme derived from a microorganism selected from Arthrobacter SC-6-98-28 strain, Arthrobacter sp. ATCC21908 strain, Chromobacterium SC-YM-1 strain, and a mutant thereof. A process is also provided for preparing an optically active azetidine-2-carboxylic acid by eliminating the N-substituent of a N-substituted azetidine-2-carboxylic acid ester of formula (2).

  提供了一种生产具有光学活性的 N-取代氮杂环丁烷-2-羧酸化合物的工艺，该化合物由式（2）代表： 将相应的式(2)N-取代的氮杂环丁烷-2-羧酸酯与一种酶接触，该酶来源于一种微生物，该微生物选自节杆菌 SC-6-98-28 株、节杆菌 ATCC21908 株、色杆菌 SC-YM-1 株及其突变体。还提供了一种通过消除式（2）N-取代的氮杂环丁烷-2-羧酸酯的 N-取代基来制备光学活性氮杂环丁烷-2-羧酸的工艺。
• Novel Ligands and Libraries of Ligands
  申请人：Braisted Andrew C.

  公开号：US20120077711A1

  公开（公告）日：2012-03-29

  The present invention provides compounds and libraries of compounds having formula (I): wherein L, n, S and A are defined generally and subsets herein. These compounds and libraries of compounds are useful generally in the drug discovery process.
• US6143554A
  申请人：——

  公开号：US6143554A

  公开（公告）日：2000-11-07
• US9850225B2
  申请人：——

  公开号：US9850225B2

  公开（公告）日：2017-12-26