2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic acid | 340309-41-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic acid
• 英文别名: 2-(2,5-dimethylpyrrol-1-yl)-5-hydroxybenzoic acid
• CAS: 340309-41-3
• 化学式: C₁₃H₁₃NO₃
• mdl: MFCD02108880
• 分子量: 231.25
• InChiKey: BTNJQFIFTBDRAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  62.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PYRROL-1 -YL BENZOIC ACID DERIVATES USEFUL AS MYC INHIBITORS<br/>[FR] DÉRIVÉS D'ACIDE PYRROL-1-YL-BENZOÏQUE UTILES EN TANT QU'INHIBITEURS DE MYC
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2014071247A1

  公开（公告）日：2014-05-08

  The present invention provides compounds of Formula (I-A), (I-B), and (I-C), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting Myc (e.g., c-Myc) activity. The present invention further provides methods of using the compounds described herein for treating Myc-mediated disorders (e.g., cancer and other proliferative diseases). The present invention also provides assays for identifying Myc inhibitors.

  本发明提供了式(I-A)、(I-B)和(I-C)的化合物、药用可接受的盐及其药用组合物。本发明的化合物可用于抑制Myc（例如，c-Myc）活性。本发明进一步提供了使用所述化合物治疗Myc介导的疾病（例如，癌症和其他增殖性疾病）的方法。本发明还提供了用于识别Myc抑制剂的检测方法。
• PYRROL-1-YL BENZOIC ACID DERIVATIVES USEFUL AS MYC INHIBITORS
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20150291521A1

  公开（公告）日：2015-10-15

  The present invention provides compounds of Formula (I-A), (I-B), and (I-C), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting Myc (e.g., c-Myc) activity. The present invention further provides methods of using the compounds described herein for treating Myc-mediated disorders (e.g., cancer and other proliferative diseases). The present invention also provides assays for identifying Myc inhibitors.

  本发明提供了公式(I-A)、(I-B)和(I-C)的化合物，其药学上可接受的盐以及其制药组合物。本发明的化合物可用于抑制Myc（例如c-Myc）的活性。本发明还提供了使用本文所描述的化合物治疗Myc介导的疾病（例如癌症和其他增殖性疾病）的方法。本发明还提供了用于鉴定Myc抑制剂的检测方法。
• METHOD FOR IDENTIFYING MYC INHIBITORS
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：EP2917203B1

  公开（公告）日：2019-04-03
• Non-Peptidic Inhibitors of AKAP/PKA Interaction
  申请人：Klussmann Enno

  公开号：US20090176773A1

  公开（公告）日：2009-07-09

  The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non-peptidic compounds or recognition molecules directed to said compounds, such as e.g. antibodies or chelating agents. The invention also relates to a pharmaceutical agent, especially for use in the treatment of diseases that are associated with a disturbance of the cAMP signal path, especially insipid diabetes, hypertonia, pancreatic diabetes, duodenal ulcer, asthma, heart failure, obesity, AIDS, edema, hepatic cirrhosis, schizophrenia and others. The invention also relates to the use of the inventive molecules.
• US9567301B2
  申请人：——

  公开号：US9567301B2

  公开（公告）日：2017-02-14