2'-Butylcarbamoyl-4,5-dimethoxy-6'-nitro-biphenyl-2-carboxylic acid | 144222-49-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-Butylcarbamoyl-4,5-dimethoxy-6'-nitro-biphenyl-2-carboxylic acid
• 英文别名: 2-[2-(Butylcarbamoyl)-6-nitrophenyl]-4,5-dimethoxybenzoic acid
• CAS: 144222-49-1
• 化学式: C₂₀H₂₂N₂O₇
• 分子量: 402.404
• InChiKey: ZRWLJLZBSUUONG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-iodo-3-nitrobenzoyl chloride 在 铜 正丁胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2'-Butylcarbamoyl-4,5-dimethoxy-6'-nitro-biphenyl-2-carboxylic acid
  参考文献：
  名称：

  An efficient synthesis of highly functionalized unsymmetrical biphenyls having substituents on the ortho positions

  摘要：

  The highly functionalized unsymmetrical biphenyls having electron-donating and/or electron-withdrawing substituents on the ortho positions were effectively synthesized based on the intramolecular Ullmann coupling reaction directed by salicyl alcohol as a template, followed by selective cleavage of the two ester bonds of S.

  DOI：

  10.1016/s0040-4039(00)61201-7

文献信息

• An efficient synthesis of highly functionalized unsymmetrical biphenyls having substituents on the ortho positions
  作者：Masami Takahashi、Yasunori Moritani、Tsuyoshi Ogiku、Hiroshi Ohmizu、Kazuhiko Kondo、Tameo Iwasaki

  DOI：10.1016/s0040-4039(00)61201-7

  日期：1992.8

  The highly functionalized unsymmetrical biphenyls having electron-donating and/or electron-withdrawing substituents on the ortho positions were effectively synthesized based on the intramolecular Ullmann coupling reaction directed by salicyl alcohol as a template, followed by selective cleavage of the two ester bonds of S.