4'-(4-Isopropyl-phenyl)-[2,2';6',2'']terpyridine | 158014-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4'-(4-Isopropyl-phenyl)-[2,2';6',2'']terpyridine
• 英文别名: 4-(4-Propan-2-ylphenyl)-2,6-dipyridin-2-ylpyridine
• CAS: 158014-68-7
• 化学式: C₂₄H₂₁N₃
• 分子量: 351.451
• InChiKey: SLLZLLDZZPHLRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙酰基吡啶 、 4-异丙基苯甲醛 在 ammonium hydroxide 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 4'-(4-Isopropyl-phenyl)-[2,2';6',2'']terpyridine
  参考文献：
  名称：

  A new light-scattering sensor for screening G-quadruplex stabilizers based on DNA-folding-mediated assembly of gold nanoparticles

  摘要：

  在这篇论文中，我们利用光散射技术组装了富含鸟嘌呤（G-rich）ssDNA 的金纳米粒子，并在此基础上构建了一种用于筛选 G-四重链稳定剂的生物传感器。我们合成了一系列金属-三吡啶配合物，并利用该生物传感器研究了它们对四重 DNA 的亲和力。利用光散射峰强度（I - I0）/I0 的比值，可以直观地呈现出稳定 G 型四链 DNA 的能力顺序：复合物 1 > 复合物 3 > MTX > 复合物 2 > 复合物 5 > 复合物 6 > 复合物 7 > 复合物 4 > 甲基绿 > TO > 复合物 8 > 顺铂。由于我们的方法可以定量分析稳定剂的亲和力，因此得到的复合物 1、复合物 3、MTX、复合物 2、复合物 5、复合物 6、复合物 7、复合物 4、甲基绿、TO 和复合物 8 的 EC50 值分别为 4.8、5.3、6.1、6.6、6.7、18.2、20.2、21.5、32.2、41.5 和 48.1 μM。这些结果已通过 G-四联体荧光插层置换（G4-FID）分析得到验证。所提出的方法是一种简单、方便、直观和高灵敏度的筛选 G-四叉稳定剂的检测方法。我们开发的生物传感器为筛选抗癌药物提供了一种前景广阔的工具。

  DOI：

  10.1039/c3tb20291g

文献信息

• Use of metal complex compounds as catalysts for oxidation using molecular oxygen or air
  申请人：Wieprecht Torsten

  公开号：US20060019853A1

  公开（公告）日：2006-01-26

  Use, as a catalyst for oxidation reactions using molecular oxygen and/or air, of at least one metal complex compound of formula (1) wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, Y is a counter-ion, q=z/(charge of Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen; unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —SR 13 , —SO 2 R 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —NR 14 R 15 ; —(C 1 -C 6 alkylene)-NR 14 R 15 ; —N (+) R 14 R 15 R 16 ; —(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16 ; —N(R 13 )—(C 1 -C 6 alkylene)-NR 14 R 15 ; —N[(C 1 -C 6 alkylene)-NR 14 R 15 ] 2 ; —N(R 13 )—(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16 ; —N[(C 1 -C 6 alkylene)-N (+) R 14 R 15 R 16]2 ; —N(R 13 )—N—R 14 R 15 or —N(R 13 )N″R 14 R 15 R 16 , wherein R 13 is as defined above and R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 , together with the nitrogen atom linking them, form an unsubstituted or substituted 5-, 6- or 7-membered ring which may contain further hetero atoms. [L n Me m X p ] z Y q (1)

  使用至少一种具有以下式（1）的金属配合物化合物作为氧化反应的催化剂，其中Me为锰、钛、铁、钴、镍或铜，X为配位或桥联基团，n和m分别独立地为1至8之间的整数，p为0至32之间的整数，z为金属配合物的电荷，Y为对离子，q=z/(Y的电荷)，L为具有以下式（2）的配体，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11各自独立地为氢；未取代或取代的C1-C18烷基或芳基；氰基；卤素；硝基；—COOR12或—SO3R12，其中R12在每种情况下为氢、阳离子或未取代或取代的C1-C18烷基或芳基；—SR13、—SO2R13或—OR13，其中R13在每种情况下为氢或未取代或取代的C1-C18烷基或芳基；—NR14R15；—(C1-C6烷基)-NR14R15；—N(+)R14R15R16；—(C1-C6烷基)-N(+)R14R15R16；—N(R13)—(C1-C6烷基)-NR14R15；—N[(C1-C6烷基)-NR14R15]2；—N(R13)—(C1-C6烷基)-N(+)R14R15R16；—N[(C1-C6烷基)-N(+)R14R15R16]2；—N(R13)—N—R14R15或—N(R13)N″R14R15R16，其中R13如上定义，R14、R15和R16各自独立地为氢或未取代或取代的C1-C18烷基或芳基，或R14和R15与连接它们的氮原子一起形成未取代或取代的5、6或7成员环，该环可能含有进一步的杂原子。[LnMemXp]zYq（1）
• Use of metal complex compounds as oxidation catalysts
  申请人：——

  公开号：US20040142843A1

  公开（公告）日：2004-07-22

  Use of metal complex compounds of formula (1): [L n Me m X p ] z Y q wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, y is a counter-ion, q=z/(charge Y), and L is a ligand of formula (2) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are each independently of the others hydrogen; unsubstituted or substituted C 1 -C 18 alkyl or aryl; cyano; halogen; nitro; —COOR 12 or —SO 3 R 12 wherein R 12 is in each case hydrogen, a cation or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —SR 13 , —OR 13 or —OR 13 wherein R 13 is in each case hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl; —N(R 13 )—NR′ 13 R″ 13 wherein R 13 , R′ 13 and R″ 13 are as defined above for R 13 ; —NR 14 R 15 or —N + R 14 R 15 R 16 wherein R 14 , R 15 and R 16 are each independently of the other(s) hydrogen or unsubstituted or substituted C 1 -C 18 alkyl or aryl, or R 14 and R 15 together with the nitrogen atom bonding them form an unsubstituted or substituted 5 -, 6 - or 7 -membered ring which may optionally contain further hetero atoms; with the proviso that R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , and R 11 are not simultaneously hydrogen, as catalysts for oxidation reactions, and the novel metal complex compounds of formula (1) and the novel ligands of formula (2). 1

  使用公式（1）的金属配合物化合物：[LnMemXp]zYq，其中Me是锰、钛、铁、钴、镍或铜，X是配位或桥联基团，n和m分别独立地为1至8的整数，p为0至32的整数，z是金属配合物的电荷，y是反离子，q=z/（反离子Y的电荷），L是公式（2）的配体，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11各自独立地为氢；未取代或取代的C1-C18烷基或芳基；氰基；卤素；硝基；—COOR12或—SO3R12，其中R12在每种情况下为氢、阳离子或未取代或取代的C1-C18烷基或芳基；—SR13、—OR13或—OR13，其中R13在每种情况下为氢或未取代或取代的C1-C18烷基或芳基；—N（R13）—NR'13R"13，其中R13、R'13和R"13如上所定义为R13；—NR14R15或—N+R14R15R16，其中R14、R15和R16各自独立地为氢或未取代或取代的C1-C18烷基或芳基，或者R14和R15与其结合的氮原子形成未取代或取代的5-、6-或7-成员环，该环可以选择性地包含进一步的杂原子；但是，R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11不能同时为氢，作为氧化反应的催化剂，以及公式（1）的新金属配合物化合物和公式（2）的新配体。
• Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
  申请人：Brown Larry

  公开号：US20050048127A1

  公开（公告）日：2005-03-03

  The invention provides homogeneous small spherical particles of low molecular weight organic molecules, said small spherical particles having a uniform shape, a narrow size distribution and average diameter of 0.01-200 μm. The invention further provides methods of preparation and methods of use of the small spherical particles. These small spherical particles are suitable for applications that require delivery of micron-size or nanosized particles with uniform size and good aerodynamic or flow characteristics. Pulmonary, intravenous, and other means of administration are among the delivery routes that may benefit from these small spherical particles.

  本发明提供了低分子量有机分子的均匀小球形粒子，这些小球形粒子具有均匀的形状、狭窄的尺寸分布和平均直径为0.01-200微米。该发明还提供了制备方法和使用方法。这些小球形粒子适用于需要传递具有均匀尺寸和良好空气动力学或流动特性的微米级或纳米级颗粒的应用。肺部、静脉和其他给药途径可能从这些小球形粒子中获益。
• Use of metal complex compounds comprising pyridine pyrimidine or s-triazine derived ligands as catalysts for oxidations with organic peroxy acids and/or precursors of organic peroxy acids and h202
  申请人：Wieprecht Torsten

  公开号：US20090189119A1

  公开（公告）日：2009-07-30

  The invention accordingly relates to the use as catalysts of at least one metal complex of formula (1) [L n Me m X p ] z Y q (1), wherein all substituents have the meanings as defined in the claims for oxidation reactions with organic peroxy acids and/or precursors of organic peroxy acid and H 2 O 2 , as well as to novel detergent compositions.

  该发明涉及使用至少一个化合物的金属配合物作为催化剂，该化合物的化学式为（1）[LnMemXp]zYq(1)，其中所有取代基的含义如权利要求所定义，用于有机过氧酸和/或有机过氧酸前体以及H2O2的氧化反应，以及新型洗涤剂组合物。
• PHARMACEUTICAL USE OF TERPYRIDINE DERIVATIVE
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0677293A1

  公开（公告）日：1995-10-18

  A terpyridine derivative represented by general formula (I) (wherein R represents hydrogen, (un)substituted phenyl, pyridyl, etc.), which has the effect of promoting the production of nerve growth factors or a neurotrophic factor activity. Hence it can be used as an ameliorant or remedy for the symptoms and diseases accompanying peripheral nerve degeneration which is idiopathic or caused by trauma, chemicals such as alcohol or anticancer drug, inflammation, or metabolism as observed in, for example, diabetes. In addition, it can be used as an ameliorant or remedy for the symptoms and diseases accompanying central nerve degeneration, such as senile dementia of Alzheimer type, cerebrovascular dementia, Down's syndrome, Parkinson's disease or Hantington's chorea, mental and motor function incompetences caused by cerebral ischemia, cerebral infarction, cerebral hemorrhage or head injury, spinal neuroparalysis, and so forth.

  一种由通式(I)代表的terpyridine衍生物（其中R代表氢、（未）取代的苯基、吡啶基等），具有促进神经生长因子或神经营养因子活性产生的作用。因此，它可作为一种改善剂或治疗剂，用于治疗特发性或由创伤、化学物质（如酒精或抗癌药物）、炎症或代谢（如糖尿病）引起的伴随周围神经变性的症状和疾病。此外，它还可用于改善或治疗中枢神经退化引起的症状和疾病，如阿尔茨海默型老年痴呆、脑血管性痴呆、唐氏综合征、帕金森病或汉廷顿舞蹈症、脑缺血、脑梗塞、脑出血或头部损伤引起的精神和运动功能障碍、脊髓神经麻痹等。