N^α-(5-oxo-prolyl)-histidine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^α-(5-oxo-prolyl)-histidine
• 英文别名: PyroGlu-His；3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoic acid
• 化学式: C₁₁H₁₄N₄O₄
• mdl: MFCD00468969
• 分子量: 266.257
• InChiKey: XFWCSGJOVUQCME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Thyrotropin-releasing hormone analogues and their therapeutic applications
  申请人：——

  公开号：US20030232966A1

  公开（公告）日：2003-12-18

  The present invention relates to novel metabolically stable and centrally active TRH analogues and prodrug forms of these analogues, wherein a functional portion of TRH is substituted with a pyridinium moiety or an ester moiety. Methods of synthesis and use of the TRH analogues and associated prodrugs are also provided.

  本发明涉及新的代谢稳定和具有中枢活性的 TRH 类似物以及这些类似物的原药形式，其中 TRH 的功能部分被吡啶基或酯基取代。还提供了合成和使用 TRH 类似物及相关原药的方法。
• METHOD AND KIT FOR ADMIINISTERING GAMMA-GLUTAMYL-D-CYSTEINE FOR THE PREVENTION OF REPERFUSION INJURY FOLLOWING ISCHEMIC STROKE
  申请人：PETERSON Darryl R.

  公开号：US20140024715A1

  公开（公告）日：2014-01-23

  The present invention provides a method for preventing blood-brain barrier reperfusion injury in a mammalian blood-brain barrier endothelial cell during reperfusion following ischemic stroke comprising administering an effective amount of a γ-glutamyl-D-cysteine antioxidant to the subject and a kit for doing the same.
• METHOD AND KIT FOR ADMINISTERING GAMMA-GLUTAMYL-D-CYSTEINE FOR THE PREVENTION OF REPERFUSION INJURY FOLLOWING ISCHEMIC STROKE
  申请人：PETERSON Darryl R.

  公开号：US20160193167A9

  公开（公告）日：2016-07-07

  The present invention provides a method for preventing blood-brain barrier reperfusion injury in a mammalian blood-brain barrier endothelial cell during reperfusion following ischemic stroke comprising administering an effective amount of a γ-glutamyl-D-cysteine antioxidant to the subject and a kit for doing the same.
• US4025499A
  申请人：——

  公开号：US4025499A

  公开（公告）日：1977-05-24
• US4242256A
  申请人：——

  公开号：US4242256A

  公开（公告）日：1980-12-30