(4-Methoxyphenyl) 2-aminoacetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4-Methoxyphenyl) 2-aminoacetate
• 化学式: C₉H₁₁NO₃
• 分子量: 181.19
• InChiKey: SROMXJFFEIBJCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Inhibitors of cathepsin S
  申请人：IRM LLC

  公开号：US20040198780A1

  公开（公告）日：2004-10-07

  The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

  本发明提供了用于选择性抑制蛋白酶S的化合物、组合物和方法。在一个优选方面，当至少存在另一种蛋白酶同工酶（例如，蛋白酶K）时，选择性地抑制蛋白酶S。本发明还提供了通过选择性抑制蛋白酶S来治疗受试者疾病状态的方法。
• [EN] SITE-SELECTIVE MODIFICATION OF PROTEINS<br/>[FR] MODIFICATION DE PROTÉINES SÉLECTIVE D'UN SITE
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2022090520A1

  公开（公告）日：2022-05-05

  The present invention concerns a method for site-selective modification of a target protein or peptide by use of an acylation tag comprising a single lysine residue and at least three histidine residues. Upon contact with an acylating reagent, the target protein or peptide becomes modified at the ε-amine of the lysine residue of the acylation tag.

  本发明涉及一种使用酰化标签对目标蛋白质或肽的位点选择性修饰的方法，该酰化标签包括一个单个赖氨酸残基和至少三个组氨酸残基。当与酰化试剂接触时，目标蛋白质或肽在酰化标签的赖氨酸残基的ε-氨基上发生修饰。
• Antibiotic intermediates
  申请人：ELI LILLY AND COMPANY

  公开号：EP0254578A1

  公开（公告）日：1988-01-27

  2,5-Disubstituted oxazolidin-4-one-3-ylacetyl chlorides and 1,2,5-substituted imidazolidin-4-one-3-yl-­acetyl chlorides function as chiral auxiliary moieties in the asymmetric cycloaddition with aldimines to pro­vide cis-azetidinones. The azetidinones are useful intermediates in the preparation of antibiotics.

  2,5-二取代的噁唑烷-4-酮-3-基乙酰氯和 1,2,5-取代的咪唑烷-4-酮-3-基乙酰氯在与醛亚胺的不对称环化反应中作为手性辅助分子提供顺式氮杂环丁酮。氮杂环丁酮是制备抗生素的有用中间体。
• US7109243B2
  申请人：——

  公开号：US7109243B2

  公开（公告）日：2006-09-19
• [EN] INHIBITORS OF CATHEPSIN S<br/>[FR] INHIBITEURS DE CATHEPSINE S
  申请人：IRM LLC

  公开号：WO2004084842A2

  公开（公告）日：2004-10-07

  The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.