Octadecenoamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Octadecenoamide
• 英文别名: octadec-2-enamide
• 化学式: C₁₈H₃₅NO
• 分子量: 281.5
• InChiKey: MHKBSCHWKVCLJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Fatty-acid amide hydrolase
  申请人：The Scripps Research Institute

  公开号：US20020187542A1

  公开（公告）日：2002-12-12

  The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of cis-9,10-octadecenoamide by FAAH leads to the formation of oleic acid, a compound without soporific activity. FAAH has be isolated and the gene encoding FAAH has been cloned, sequenced, and used to express recombinant FAAH. Inhibitors of FAAH are disclosed to block the hydrolase activity.

  顺式-9,10-辛二烯酰胺和其他催眠性脂肪酸主要酰胺的催眠活性在存在脂肪酸酰胺水解酶（FAAH）时被水解中和。FAAH对顺式-9,10-辛二烯酰胺的水解导致油酸的形成，这是一种没有催眠活性的化合物。FAAH已被分离出来，编码FAAH的基因已被克隆、测序，并用于表达重组FAAH。抑制FAAH的化合物被揭示可阻断水解酶活性。
• [EN] METHODS TO RELIEF PAIN<br/>[FR] PROCEDES POUR SOULAGER LA DOULEUR
  申请人：IMP COLLEGE INNOVATIONS LTD

  公开号：WO2005079771A1

  公开（公告）日：2005-09-01

  Use of a compound of Formula (I) RC(O)-NH-(CH2)n-CH=CH2, wherein R represents C1-20 alkyl, C2-20 alkenyl or C2-20 alkynyl; and n is an integer from 0 to 3, in the manufacture of a medicament for use in pain relief. A compound of Formula (I) for use in medicine. A method of providing pain relief to a patient comprising administering to said patient an effective amount of a compound of Formula (I). A preferred compound is N-(2propenyl) hexadecanamide.

  使用式（I）中的化合物RC(O)-NH-(CH2)n-CH=CH2，其中R代表C1-20烷基，C2-20烯基或C2-20炔基；n为0到3的整数，在制造用于缓解疼痛的药物中的用途。用于医药的式（I）化合物。一种提供疼痛缓解给患者的方法，包括向该患者施用式（I）化合物的有效量。一种首选的化合物是N-(2丙烯基)十六烷酰胺。
• Strontium and barium containing alkoxylation systems
  申请人：Conoco Inc.

  公开号：EP0046947A1

  公开（公告）日：1982-03-10

  Basic compounds and salts of strontium and barium, and the metals themselves, are used to catalyze the formation of propylene oxide, ethylene oxide and propylene oxide/ethylene oxide adducts of a variety of organic compounds. Materials containing polvols, carboxylic acids, amines, phenols, mercaptans, alkanols, and amides can be reacted to form these adducts. Reactions products have peaked distributions, low pour points, and low levels of unreacted starting materials. Reactions are normally carried out at temperatures of from about 90 to about 260°C.

  锶和钡的碱性化合物和盐类以及金属本身可用于催化多种有机化合物形成环氧丙烷、环氧乙烷和环氧丙烷/环氧乙烷加合物。 含多酚、羧酸、胺、酚、硫醇、烷醇和酰胺的材料可通过反应形成这些加合物。 反应产物呈峰值分布，倾点低，未反应的起始材料含量低。 反应通常在约 90 至约 260°C 的温度下进行。
• Strontium and barium containing alkoxylation systems for unsaturated alcohols
  申请人：Conoco Inc.

  公开号：EP0049358A1

  公开（公告）日：1982-04-14

  Basic compounds and salts of strontium and barium, and the metals themselves, are used to catalyze the formation of propylene oxide, ethylene oxide and propylene oxide'ethylene oxide adducts of unsaturated alcohols. Reaction products have peaked distributions, low pour points, and low levels of unreacted starting materials. Reactions are normally carried out at temperatures of from about 90 to about 260°C.

  锶和钡的碱性化合物和盐以及金属本身可用于催化不饱和醇形成环氧丙烷、环氧乙烷和环氧丙烷环氧乙烷加合物。反应产物呈峰值分布，倾点低，未反应的起始物质含量低。反应通常在约 90 至约 260°C 的温度下进行。
• Automotive interior compound
  申请人：Borealis AG

  公开号：EP2386602A1

  公开（公告）日：2011-11-16

  Composition having a melt flow rate MFR2 (230 °C) measured according to ISO 1133 in the range of 15 to 30 g/10min, said composition comprises a heterophasic propylene copolymer (H-PP1), a high melt flow polypropylene (HMF-PP), a styrenic block copolymer (SBC) and a mineral filler (F), wherein (a) the heterophasic propylene copolymer (H-PP1) has a xylene cold soluble (XCS) content measured according to ISO 6427 in the range of 22.0 to 50.0 wt.-% and comprises (a1) a polypropylene matrix (M1) and (a2) an elastomeric copolymer (E1) comprising units derived from - propylene and - ethylene and/or C4 to C12 α-olefin, (b) the melt flow rate MFR2 (230 °C) measured according to ISO 1133 of the high melt flow polypropylene (HMF-PP) is higher than the melt flow rate MFR2 (230 °C) measured according to ISO 1133 of the heterophasic propylene copolymer (H-PP1), and (c) the high melt flow polypropylene (HMF-PP) has melt flow rate MFR2 (230 °C) measured according to ISO 1133 of at least 40.0 g/10min.

  根据 ISO 1133 测量，熔体流动速率 MFR2（230 °C）在 15 至 30 克/10 分钟范围内的组合物、 所述组合物包括杂相丙烯共聚物 (H-PP1)、高熔体流动性聚丙烯 (HMF-PP)、苯乙烯嵌段共聚物 (SBC) 和矿物填料 (F)，其中 (a) 异相丙烯共聚物(H-PP1)的二甲苯冷溶性(XCS)含量根据 ISO 6427 测定在 22.0 至 50.0 wt.-%之间，并包括 (a1) 聚丙烯基体（M1）和 (a2) 弹性共聚物 (E1)，该共聚物由以下单元组成 - 丙烯和 - 乙烯和/或 C4 至 C12 α-烯烃的单元组成、 (b) 高熔体流动聚丙烯（HMF-PP）根据 ISO 1133 测得的熔体流动速率 MFR2（230 ℃）高于杂相丙烯共聚物（H-PP1）根据 ISO 1133 测得的熔体流动速率 MFR2（230 ℃）、 以及 (c) 根据 ISO 1133 测量，高熔体流动性聚丙烯（HMF-PP）的熔体流动性 MFR2（230 ℃）至少为 40.0 克/10 分钟。