prop-2-enyl N-ethylcarbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: prop-2-enyl N-ethylcarbamate
• 化学式: C₆H₁₁NO₂
• 分子量: 129.16
• InChiKey: WUHLCILFNNVBCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL FIVE-MEMBERED RING COMPOUND
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP2272835A1

  公开（公告）日：2011-01-12

  Disclosed is a five-membered ring compound represented by formula (1) or a pharmaceutically acceptable salt thereof. The compound inhibits infiltration of leukocytes including eosinophils and lymphocytes, and is effective as a drug for treating various inflammations. The compound is highly safe and can be administered for a long period. A pharmaceutical product containing the five-membered ring compound or a pharmaceutically acceptable salt thereof is also disclosed. (In the formula, R1 represents a halogen atom or a phenyl group which may be substituted by a C1-C3 alkyl group or a C1-C3 alkoxy group; R2 represents a C1-C3 alkylene group which may be substituted by a C1-C3 alkyl group or a carbonyl group; R3 represents a C1-C3 alkyl group; R4 and R5 independently represent a hydrogen atom or a C1-C3 alkyl group, or -N(R4)R5 may represent a morpholino group which may be substituted by a C1-C3 alkyl group; Y2 represents a C2-C4 alkylene group; and R6 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group or a C1-C3 alkoxy group.)

  揭示了一种由式（1）表示的五元环化合物或其药用可接受的盐。该化合物抑制包括嗜酸性粒细胞和淋巴细胞在内的白细胞浸润，并且作为治疗各种炎症的药物非常有效。该化合物非常安全，并且可以长期使用。还公开了含有该五元环化合物或其药用可接受的盐的药物产品。（在式中，R1代表卤素原子或可能被C1-C3烷基或C1-C3烷氧基取代的苯基；R2代表可能被C1-C3烷基或羰基取代的C1-C3烷基；R3代表C1-C3烷基；R4和R5独立地代表氢原子或C1-C3烷基，或-N(R4)R5可能代表可能被C1-C3烷基取代的吗啡基；Y2代表C2-C4烷基；R6代表氢原子、卤素原子、C1-C3烷基或C1-C3烷氧基。)
• [EN] NOVEL ARYL-CYANOGUANIDINE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS D'ARYL-CYANOGUANIDINE
  申请人：BAYER PHARMA AG

  公开号：WO2016091845A1

  公开（公告）日：2016-06-16

  The present invention relates to protein-lysine N-methyltransferase SMYD2 (SET and MYND domain-containing protein 2) inhibitors, in particular SMYD2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (I) wherein R1, R2, R3, R4, R5, X and r have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use for hyperproliferative disorders, in particular for cancer, respectively tumour disorders. The present invention furthermore relates to the use of SMYD2 inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, neurodegenerative disorders, inflammatory disorders, atherosclerotic disorders and the control of male fertility.

  本发明涉及蛋白赖氨酸N-甲基转移酶SMYD2（SET和MYND结构域含蛋白2）抑制剂，特别是通式（I）所示的SMYD2抑制剂取代的氰胍基吡唑啉化合物，其中R1、R2、R3、R4、R5、X和r具有如下所述和定义的含义，以及包含根据本发明的化合物的药物组合物，以及它们在高增殖性疾病，特别是癌症，以及肿瘤疾病的预防和治疗中的应用。本发明还涉及将SMYD2抑制剂用于良性增生、动脉粥样硬化疾病、败血症、自身免疫性疾病、血管疾病、病毒感染、神经退行性疾病、炎症性疾病、动脉粥样硬化疾病和男性生育能力的控制。
• 10a-Azalide Compound
  申请人：Sugimoto Tomohiro

  公开号：US20090281292A1

  公开（公告）日：2009-11-12

  [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. [Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.

  【目标】提供一种具有新结构的化合物，对流感嗜血杆菌和红霉素耐药菌（例如耐药肺炎球菌和链球菌）以及传统的红霉素敏感菌具有有效作用。 【解决方案】本发明提供了一种新型10a-氮杂环十六元化合物，其化学式为（I），其药学上可接受的盐或其溶剂化物，或其制备的中间体。该化合物对流感嗜血杆菌、红霉素耐药性肺炎球菌等具有卓越的抗菌活性，因此可以作为治疗传染病的药物。
• FIVE-MEMBERED RING COMPOUND
  申请人：Fujita Hitoshi

  公开号：US20110039848A1

  公开（公告）日：2011-02-17

  Provided are: a five-membered ring compound represented by formula (1) or a pharmaceutically acceptable salt thereof; and a medicine containing the compound or salt. The compound or salt inhibits the infiltration of leukocytes such as eosinophils and lymphocytes, is effective as a therapeutic agent for various kinds of inflammation, and is so safe that the compound or salt can be taken for long. In formula (1), R 1 is (substituted) phenyl or pyridyl; R 2 is (substituted) pyrazinediyl, pyrimidinediyl, or pyridazinediyl; R 3 to R 5 each is alkyl (provided that —N(R 4 )R 5 may be morpholino); and Y 2 is alkylene.

  提供的是：由式（1）表示的五元环化合物或其药学上可接受的盐；以及含有该化合物或盐的药物。该化合物或盐抑制白细胞浸润，如嗜酸性粒细胞和淋巴细胞，对各种炎症有效，且安全性高，可长期服用。在式（1）中，R1是（取代）苯基或吡啶基；R2是（取代）吡嗪二基、嘧啶二基或吡嗪二基；R3至R5分别是烷基（但—N（R4）R5可以是吗啡基）；Y2是烷基。
• Novel depsipeptides and process for preparing same
  申请人：Cubist Pharmaceutical Inc.

  公开号：EP1932853A1

  公开（公告）日：2008-06-18

  The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and imntermediates used in producing these compounds.

  本发明涉及新型去肽化合物。本发明还涉及这些化合物的药物组合物以及将这些化合物用作抗菌化合物的方法。本发明还涉及生产这些新型去肽化合物的方法和用于生产这些化合物的中间体。