N-dodecanoylmorpholine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-dodecanoylmorpholine-4-carboxamide
• 化学式: C₁₇H₃₂N₂O₃
• 分子量: 312.4
• InChiKey: QVLVGBYVSOKRMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• USE OF COMPOUNDS AS FUNCTIONAL ANTAGONISTS TO THE CENTRAL CANNABINOID RECEPTORS
  申请人：Research & Innovation Soc. Coop. A R.L.

  公开号：EP1425004A1

  公开（公告）日：2004-06-09
• [EN] USE OF COMPOUNDS AS FUNCTIONAL ANTAGONISTS TO THE CENTRAL CANNABINOID RECEPTORS<br/>[FR] UTILISATION DE COMPOSES EN TANT QU'ANTAGONISTES FONCTIONNELS DES RECEPTEURS CANNABINOIDES CENTRAUX
  申请人：RES & INNOVATION SOC COOP A R

  公开号：WO2003006007A1

  公开（公告）日：2003-01-23

  The invention refers to the use of saturated fatty acid acylamide derivatives as functional antagonists to the central cannabinoid receptors. These molecules, per se devoid of the psychotropic effects of classic cannabinoids, aminoalkylindoles, endocannabinoids known today, have the ability to behave as functional antagonists of the central cannabinoid receptors, when administered by different routes. For their pharmacological activity they are therefore suitable as drugs in pathological states or disorder which can be controlled through a reduction in the functionality of said receptors or through a reduction of the effect of the same endocannabinoids also caused by a reduced availability or affinity of the receptors.