(8Z,11E,14E)-icosa-8,11,14-trienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (8Z,11E,14E)-icosa-8,11,14-trienoic acid
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.5
• InChiKey: HOBAELRKJCKHQD-RNCOHGIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SYNTHESIS OF FLUOROARACHIDONIC ACID AND METHODS OF USE THEREOF
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20130302247A1

  公开（公告）日：2013-11-14

  There are provided, inter alia, methods for diagnosis of the extent of neuroinflammation in a subject. The methods include administering an 18 F-labeled arachidonic acid to a subject in need thereof, obtaining a positron emission tomography (PET) scan of the subject, and determine the extent of neuroinflammation from the PET scan. There are provided, inter alia, methods of synthesis of reagents useful for the production of an 18 F-labeled arachidonic acid.

  提供了诊断受试者神经炎症程度的方法，其中包括向需要的受试者施用18F标记的花生四烯酸，获取受试者的正电子发射断层扫描（PET扫描），并根据PET扫描确定神经炎症的程度。此外，还提供了合成试剂的方法，用于生产18F标记的花生四烯酸。
• [EN] COMPOSITIONS AND METHODS OF DELIVERY OF DEUBIQUITINASE INHIBITORS<br/>[FR] COMPOSITIONS ET MÉTHODES D'ADMINISTRATION D'INHIBITEURS DE DÉUBIQUITINASE
  申请人：PHARMAKEA INC

  公开号：WO2015183987A1

  公开（公告）日：2015-12-03

  Described herein are compositions comprising deubiquitinase inhibitors in combination with albumin, methods of making such compositions, and methods of using such compositions in the treatment of conditions, diseases, or disorders that would benefit from inhibition of deubiquitinase activity.

  本文描述了含有去泛素化酶抑制剂与白蛋白组合的组合物，制备这种组合物的方法，以及利用这种组合物治疗需要抑制去泛素化酶活性的病症、疾病或紊乱的方法。
• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• METHOD FOR IMPROVING MITOPHAGY IN SUBJECTS
  申请人：Amazentis SA

  公开号：US20180256539A1

  公开（公告）日：2018-09-13

  The invention provides a compound of formula (I) wherein: A, B, C, D, W, X, Y and Z are each independently selected from H and OH; or a salt thereof; for use in the treatment and/or prophylaxis of a condition, disease or disorder in a subject, wherein the compound or salt is orally administered to a subject in a daily amount of from 2.8 to 6.6 mmol per day, over a period of at least 21 days. Also are provided are the compound of formula (I) for use in increasing mitophagy and/or autophagy, maintaining and/or improving muscle function and administration as a dietary, nutritional and/or health supplement.

  本发明提供了化合物(I)的公式，其中A、B、C、D、W、X、Y和Z各自独立地选择H和OH；或其盐；用于治疗和/或预防受试者的状况、疾病或障碍，其中该化合物或盐以每天2.8至6.6毫摩尔的剂量口服给予受试者，持续至少21天。此外，还提供了公式(I)的化合物，用于增加线粒体自噬和/或自噬作用，维持和/或改善肌肉功能，并作为膳食、营养和/或健康补充剂给予。
• Process for production of bishomo-gamma-linolenic acid
  申请人：SUNTORY LIMITED

  公开号：EP0322227A2

  公开（公告）日：1989-06-28

  A process for the production of bishomo-γ-linolenic acid characterized by adding an additive to a culture medium, which additive is preferably selected from sesame oil, peanut oil, an extract from sesame oil or sesame seeds, and a lignan compound present in the extract from sesame oil or sesame seeds. The process uses, as a producer microorganism, a microorganism capable of producing arachidonic acid.

  一种生产双γ-亚麻酸的工艺，其特征是在培养基中加入一种添加剂，该添加剂最好选自芝麻油、花生油、芝麻油或芝麻籽的提取物以及芝麻油或芝麻籽提取物中的木质素化合物。该工艺使用能够产生花生四烯酸的微生物作为生产微生物。