(2R)-2-[[N'-[(4S)-4-amino-4-carboxybutyl]carbamimidoyl]amino]butanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[[N'-[(4S)-4-amino-4-carboxybutyl]carbamimidoyl]amino]butanedioic acid
• 化学式: C₁₀H₁₈N₄O₆
• 分子量: 290.27
• InChiKey: KDZOASGQNOPSCU-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  188
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• [EN] PANTETHENOYLCYSTEINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PANTÉTHÉNOYLCYSTÉINE ET LEURS UTILISATIONS
  申请人：COMET THERAPEUTICS INC

  公开号：WO2020198573A1

  公开（公告）日：2020-10-01

  The present disclosure relates to compounds of Formula (I) or (II): (Formulae (I), (II)), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

  本公开涉及式(I)或(II)的化合物：(式(I)，(II))，以及其药用可接受的盐或溶剂化合物。本公开还涉及包含这些化合物的药物组合物，以及这些化合物和药物组合物的治疗和诊断用途。
• [EN] BRANCHED PEG MOLECULES AND RELATED COMPOSITIONS AND METHODS<br/>[FR] MOLÉCULES DE PEG RAMIFIÉ, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：PHASERX INC

  公开号：WO2018126084A1

  公开（公告）日：2018-07-05

  Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

  揭示了分支聚乙二醇（PEG）分子，包括分支PEG-脂质和分支PEG-蛋白质，以及制备分支PEG分子的相关组合物和方法。还公开了相关的组合物、系统和方法，用于体内传递治疗和诊断试剂。
• CONJUGATES FOR PROTECTION FROM NEPHROTOXIC ACTIVE SUBSTANCES
  申请人：MERCK PATENT GmbH

  公开号：US20160114054A1

  公开（公告）日：2016-04-28

  The present invention relates to a conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective action for the kidney against nephrotoxic active compounds, to a process for the preparation of the conjugate, to the use thereof for the protection of the kidney against nephrotoxic active compounds, and to a medicament comprising the conjugate.

  本发明涉及一种共轭物，其中至少包含一种选择性肾脏载体分子和至少一种对肾脏具有保护作用的活性化合物，以及制备该共轭物的方法，将其用于保护肾脏免受肾毒性活性化合物的影响，以及包含该共轭物的药物。
• PEPTIDES AND PEPTIDE/ACTIVE COMPOUND CONJUGATES FOR RENAL TARGETING
  申请人：MERCK PATENT GMBH

  公开号：US20160199505A1

  公开（公告）日：2016-07-14

  The present invention relates to a peptide which consists of more than 50% of sequence sections of the formula -(A n -B m -C o )-, and to a conjugate containing the peptide and at least one covalently bonded active compound, and to a process for the preparation of the conjugate. The present invention furthermore relates to the use of the peptide and the conjugate for targeting of the kidney, and to a medicament comprising the peptide or conjugate.

  本发明涉及一种肽，其中超过50％的序列部分符合以下公式-(An-Bm-Co)-，以及含有该肽和至少一个共价结合的活性化合物的共轭物，以及制备该共轭物的方法。本发明还涉及利用该肽和共轭物用于靶向肾脏的用途，以及包含该肽或共轭物的药物。
• [EN] NICOTINAMIDE MONONUCLEOTIDE AND NICOTINAMIDE RIBOSIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF VIRAL INFECTIONS AND RESPIRATORY COMPLICATIONS, IN PARTICULAR CAUSED BY INFLUENZAVIRUS OR CORONAVIRUS<br/>[FR] DÉRIVÉS DE NICOTINAMIDE MONONUCLÉOTIDE ET DE NICOTINAMIDE RIBOSIDE ET LEUR UTILISATION DANS LE TRAITEMENT D'INFECTIONS VIRALES ET DE COMPLICATIONS RESPIRATOIRES, PROVOQUÉES EN PARTICULIER PAR LE VIRUS DE LA GRIPPE OU LE CORONAVIRUS
  申请人：NUVAMID SA

  公开号：WO2021214299A1

  公开（公告）日：2021-10-28

  The present invention relates to Nicotinamide mononucleotide derivatives of formula (I) or (Ia) for use in the treatment and/or prevention of viral infections, such as respiratory infections. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I) or (Ia) for use in the treatment and/or prevention of viral infections.

  本发明涉及式(I)或(Ia)的烟酰胺单核苷酸衍生物，用于治疗和/或预防病毒感染，如呼吸道感染。本发明还涉及包含式(I)或(Ia)的化合物的制药组合物，用于治疗和/或预防病毒感染。