(2R^*,3R^*)-1-ethyloxycarbonyl-2,3,5-trimethyl-2,3-dihydro-<1H>-1-benzazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (2R^*,3R^*)-1-ethyloxycarbonyl-2,3,5-trimethyl-2,3-dihydro-<1H>-1-benzazepine
• 英文别名: ethyl (2R,3R)-2,3,5-trimethyl-2,3-dihydro-1-benzazepine-1-carboxylate
• 化学式: C₁₆H₂₁NO₂
• 分子量: 259.348
• InChiKey: USEQSQVGPKPOHD-DGCLKSJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氯甲酸乙酯 、 2,3,5-trimethyl-2,3-dihydro-1H-1-benzazepine 在 potassium carbonate 作用下， 以 苯 为溶剂， 反应 48.0h， 以70%的产率得到(2R^*,3R^*)-1-ethyloxycarbonyl-2,3,5-trimethyl-2,3-dihydro-<1H>-1-benzazepine
  参考文献：
  名称：

  1-Benzazepine derivatives acting as ATP-dependent potassium-channels antagonists

  摘要：

  In order to select between various pharmacological activities related to the 1-benzazepine nucleus, a set of 1-benzazepine derivatives bearing different N-1 or C-2 substituents were synthesized and tested in vitro as ATP-dependent Kf-channel antagonists on isolated guinea-pig trachea. Cumulative concentration curves to cromakalim were constructed in the absence or presence of the various compounds tested in comparison with glibenclamide. Products bearing N-1 substituents, especially (2-imidazolinyl)methyl showed a non-competitive antagonism towards ATP-dependent K+ channels.

  DOI：

  10.1016/0223-5234(96)88204-3