stampidine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: stampidine
• 英文别名: 5'-[4-bromophenyl methoxyalaninylphosphate]-2',3'-didehydro-3'-deoxy thymidine；methyl 2-[[(4-bromophenoxy)-[[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]phosphoryl]amino]propanoate
• 化学式: C₂₀H₂₃BrN₃O₈P
• 分子量: 544.296
• InChiKey: VPABMVYNSQRPBD-RNOBUQKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains
  申请人：Uckun M. Fatih

  公开号：US20070015733A1

  公开（公告）日：2007-01-18

  Methods of inhibiting virus replication of in a cell infected with a resistant strain of HIV that includes administering to the infected cell a virus replication inhibiting amount of an aryl phosphate derivative of d4T.

  抑制耐药HIV感染细胞中病毒复制的方法包括向感染的细胞中投入一定量的d4T的芳基磷酸酯衍生物，以抑制病毒的复制。
• COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE
  申请人：University of Virginia Patent Foundation

  公开号：EP3927710A1

  公开（公告）日：2021-12-29
• DDX17 AND NLRC4 TARGETING FOR INFLAMMATORY DISEASES
  申请人：University of Virginia Patent Foundation

  公开号：EP4017503A1

  公开（公告）日：2022-06-29
• [EN] COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT OU DE PRÉVENTION DE LA MALADIE D'ALZHEIMER
  申请人：UNIV VIRGINIA PATENT FOUNDATION

  公开号：WO2020185676A1

  公开（公告）日：2020-09-17

  Methods for treating and/or inhibiting progression of neurological diseases, conditions, and/or disorders. In some embodiments, the methods include administering to as subject in need thereof a composition that includes a reverse transcriptase inhibitor. Also provided are methods for inhibiting development of amyloid beta peptide (Αβ) in subjects, methods for inhibiting microglial cell death, and composition for use in the presently disclosed methods.
• [EN] DDX17 AND NLRC4 TARGETING FOR INFLAMMATORY DISEASES<br/>[FR] CIBLAGE DE DDX17 ET NLRC4 POUR DES MALADIES INFLAMMATOIRES
  申请人：UNIV VIRGINIA PATENT FOUNDATION

  公开号：WO2021041317A1

  公开（公告）日：2021-03-04

  Provided are methods for treating and/or preventing diseases, disorders, and/or conditions associated with NLR family CARD domain containing 4 (NLRC4) inflammasome biological activities. In some embodiments, the method include administering to a subject in need thereof a composition that includes a nucleoside reverse transcriptase inhibitor (NRTI). Also provided are methods for inhibiting NLRC4-induced caspase-1 activation in cells, methods for inhibiting NLRC4-induced IL-Ιβ release from cells, methods for inhibiting Alu-induced retinal pigmented cell (RPE) degeneration in subjects, and compositions for use in the presently disclosed methods.