1H-Pyrrole, 1-methyl-2-pentyl

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1H-Pyrrole, 1-methyl-2-pentyl
• 英文别名: 1-methyl-2-pentylpyrrole
• 化学式: C₁₀H₁₇N
• 分子量: 151.25
• InChiKey: GVZIOFGTDMVMSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0492171A1

  公开（公告）日：1992-07-01

  There are provided important pyrroline and glycine intermediates, methods for the preparation of said intermediates and the use thereof in the manufacture of arylpyrrole insecticidal agents.

  提供了重要的吡咯啉和甘氨酸中间体、制备上述中间体的方法及其在制造芳基吡咯杀虫剂中的用途。
• 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0826667A1

  公开（公告）日：1998-03-04

  There are provided important pyrroline and glycine intermediates, methods for the preparation of said intermediates and the use thereof in the manufacture of arylpyrrole insecticidal agents.

  提供了重要的吡咯啉和甘氨酸中间体、制备上述中间体的方法及其在制造芳基吡咯杀虫剂中的用途。
• 4-Chloro-1-(ethoxymethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile, and its use as insecticide, nematocide and acaricide
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0492171B1

  公开（公告）日：2000-08-02
• Diagnostic methods for age related macular degeneration
  申请人：Hollyfield G. Joe

  公开号：US20070072241A1

  公开（公告）日：2007-03-29

  Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in a bodily fluid which has been obtained from the test subject. In a preferred embodiment, such methods comprise providing an antibody that is immunospecific for CEP, contacting a bodily fluid from the subject with the anti-CEP antibody, and assaying for the formation of a complex between the antibody and an antigen in the sample. In another aspect, the methods comprise assaying for the presence of elevated levels of an antibody that binds to or is immunospecific for a CEP adduct in the bodily fluid of the test subject. The present invention also relates to CEP protein and peptide adducts, an antibody reactive with a CEP adduct and a diagnostic kit comprising such antibody.
• DIAGNOSTIC METHODS FOR AGE RELATED MACULAR DEGENERATION
  申请人：Hollyfield Joe G.

  公开号：US20080160505A1

  公开（公告）日：2008-07-03

  Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in a bodily fluid which has been obtained from the test subject. In a preferred embodiment, such methods comprise providing an antibody that is immunospecific for CEP, contacting a bodily fluid from the subject with the anti-CEP antibody, and assaying for the formation of a complex between the antibody and an antigen in the sample. In another aspect, the methods comprise assaying for the presence of elevated levels of an antibody that binds to or is immunospecific for a CEP adduct in the bodily fluid of the test subject. The present invention also relates to CEP protein and peptide adducts, an antibody reactive with a CEP adduct and a diagnostic kit comprising such antibody.