Pentanoic acid, 2,4-dimethyl-, t-butyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Pentanoic acid, 2,4-dimethyl-, t-butyl ester
• 英文别名: tert-butyl 2,4-dimethylpentanoate
• 化学式: C₁₁H₂₂O₂
• 分子量: 186.29
• InChiKey: PJCVELDASPSMIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• METHOD FOR THE SYNTHESIS OF PEPTIDES WITHOUT SOLVENT
  申请人：Martinez Jean

  公开号：US20100016631A1

  公开（公告）日：2010-01-21

  The disclosure relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C 1 -C 6 arylalkyl group or a C 1 -C 6 alkyl group substituted or not by an aryl group, —COOH, C 1 -C 6 , —COO-(alkyl), —CONH 2 , —SH, heteroaryl, —NH 2 , —NHC(NH)(NH 2 ), C 1 -C 6 -s-(alkyl), —OH or phenol; Ra is a N-protective group; Rc is a ORd group in which Rd is a C 1 -C 6 alkyl group or a NReRf group in which Re and Rf Re independently an N-protective group.

  披露涉及一种用于合成公式(I)化合物的方法，其中：n是大于或等于1的整数；Rb和每个Rn独立的是氢原子、C1-C6芳烷基团或由芳基团、—COOH、C1-C6、—COO-(烷基)、—CONH2、—SH、杂芳基、—NH2、—NHC(NH)(NH2)、C1-C6-s-(烷基)、—OH或酚取代或未取代的C1-C6烷基团；Ra是N-保护基团；Rc是ORd基团，其中Rd是C1-C6烷基团或NReRf基团，其中Re和Rf独立的是N-保护基团。
• METHOD FOR PREPARING VITTATALACTONE
  申请人：BREIT Bernhard

  公开号：US20110282075A1

  公开（公告）日：2011-11-17

  The present invention relates to the chemical synthesis of vittatalactone, the aggregation pheromone of the striped cucumber beetle, Acalymma vittatum.

  本发明涉及条纹黄瓜甲（Acalymma vittatum）聚集信息素vittatalactone的化学合成。
• Substituted 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-2-ylamine Compounds and Their Use for Producing Drugs
  申请人：Frank Robert

  公开号：US20080300256A1

  公开（公告）日：2008-12-04

  Substituted 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-ylamine compounds corresponding to formula I, methods for the preparation thereof, pharmaceutical compositions containing said compounds, the use of said compounds for preparing pharmaceutical compositions and related treatment methods.

  替代5,6,7,8-四氢咪唑[1,2-a]吡啶-2-胺化合物的公式I，其制备方法，含有该化合物的药物组合物，使用该化合物制备药物组合物以及相关治疗方法。
• DERIVATIVES OF FLUORENE, ANTHRACENE, XANTHENE, DIBENZOSUBERONE AND ACRIDINE AND USES THEREOF
  申请人：Cholody Wieslaw M.

  公开号：US20100137354A1

  公开（公告）日：2010-06-03

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明涉及化学剂，例如荧光烯，蒽，三苯甲烷和吖啶的二磺酰胺衍生物，以及类似的杂环环结构及其盐，这些化学剂作为抗癌和抗肿瘤剂，特别是当这些剂调节Wnt/β-连环蛋白信号通路的活性时，并能降低β-连环蛋白在细胞中（如癌细胞）的水平，或当这些剂调节细胞系统（包括癌细胞）的基因表达水平时。此外，本发明还揭示了制备这些化学剂的方法，以及包含这些化学剂作为活性成分的制药组合物和使用它们作为治疗剂的方法。
• Derivatives of Fluorene, Anthracene, Xanthene, Dibenzosuberone and Acridine and Uses Thereof
  申请人：Cholody Wieslaw M.

  公开号：US20120129837A1

  公开（公告）日：2012-05-24

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明涉及一种化学试剂，例如芴，蒽，黄色素，二苯基甲酮和吖啶的二磺酰胺衍生物，以及类似的杂环环结构，包括其盐，作为抗癌和抗肿瘤试剂，特别是这些试剂能够调节Wnt/β-连环蛋白信号通路的活性，降低细胞中（如癌细胞）的β-连环蛋白水平，或者这些试剂调节细胞系统（包括癌细胞）中基因表达水平。同时，本发明还涉及制备这些试剂的方法，以及包含这些试剂作为活性成分的制药组合物和使用这些组合物作为治疗试剂的方法。