8-环丁基-8-氧代辛酸 | 898766-85-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: 8-环丁基-8-氧代辛酸
• 英文名称: 8-Cyclobutyl-8-oxooctanoic acid
• CAS: 898766-85-3
• 化学式: C₁₂H₂₀O₃
• 分子量: 212.28
• InChiKey: PFFDQUOOAOYQHO-UHFFFAOYSA-N

物化性质

• 沸点：
  382.3±25.0 °C(Predicted)
• 密度：
  1.083±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918300090

文献信息

• [EN] BIOORTHOGONAL COMPOSITIONS<br/>[FR] COMPOSITIONS BIO-ORTHOGONALES
  申请人：SHASQI INC

  公开号：WO2017044983A1

  公开（公告）日：2017-03-16

  The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.

  本公开提供了用于在受试者中传递药剂的生物正交组合物。该公开还提供了生产这些组合物的方法，以及使用相同的方法。
• Affinity resin
  申请人：Tanaka Akito

  公开号：US20070167594A1

  公开（公告）日：2007-07-19

  A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are capable of reducing the non-specific adsorption of substances, other than the target molecule for the ligand, which mingle in the sample, to the resin and/or the ligand. Therefore, target molecule search, identification and the like with less noise are enabled.

  一种树脂通过聚合包含亲水间隔的单体组分，以及通过将配体固定在树脂上获得的配体固定化固相载体，能够减少除了配体的目标分子以外的杂质在样品中与树脂和/或配体结合的非特异性吸附。因此，可以实现更少噪音的目标分子搜索、鉴定等。
• METHOD OF CALIBRATING LIGAND SPECIFICITY
  申请人：Tanaka Akito

  公开号：US20090305435A1

  公开（公告）日：2009-12-10

  A method to determine specificity of ligand binding includes comparing a solid phase carrier first extract obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a solid phase carrier second extract obtained by treating the pretreated sample again with a ligand-immobilized solid phase carrier in terms of the proteins contained therein, and identifying a protein whose content is remarkably decreased in the second extract compared to the first extract, in order to solve 1 ) the problem of the solubility of subject ligand, 2 ) the problem of the non-specific protein-denaturing effect of the subject ligand added, and the like, in antagonism experiments in target search using an affinity resin.

  一种确定配体结合特异性的方法，包括比较通过用配体固定的固相载体预处理样品得到的固相载体第一提取物和再次用配体固定的固相载体处理预处理样品得到的固相载体第二提取物，其蛋白质含量，识别在第二提取物中与第一提取物相比明显减少的蛋白质，以解决在亲和树脂进行靶标搜索的拮抗实验中，目标配体的溶解度问题、添加的目标配体的非特异性蛋白变性效应等问题。
• Method for Suppressing Intermolecular Nonspecific Interaction and for Intensifying Intermolecular Specific Interaction on Metal Surface
  申请人：Tanaka Akito

  公开号：US20080176341A1

  公开（公告）日：2008-07-24

  The present invention provides a method of searching for a target molecule for a ligand immobilized on a metal surface or analyzing the interaction between a ligand and a target molecule, characterized in that the immobilization of the ligand on the metal surface via a hydrophilic spacers, and the method eliminates or suppresses a nonspecific interaction that prevents analysis of intermolecular interaction on a metal surface, and can intensify specific intermolecular interactions.

  本发明提供了一种寻找固定在金属表面上的配体的靶分子或分析配体与靶分子之间相互作用的方法。其特征在于，通过亲水性间隔物将配体固定在金属表面上，该方法消除或抑制了阻止在金属表面上分析分子间相互作用的非特异性相互作用，并能增强特异性分子间相互作用。
• Method of treating cancer
  申请人：Intensity Therapeutics, Inc.

  公开号：US10888618B2

  公开（公告）日：2021-01-12

  The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and optionally in further combination with local administration of an immunotherapeutic agent, such as a cancer vaccine or NKT agonist. The invention also provides a method for treating cancer using an intracellular penetration enhancing agent. The methods of the invention aim to substantially kill and/or destroy the target tumor cells, as well as those cancerous cells that have metastasized to other parts of the body.

  本发明提供了一种使用联合给药策略治疗癌症的方法，该策略结合了治疗剂和细胞内渗透增强剂的局部联合给药，并可选择进一步结合免疫治疗剂（如癌症疫苗或 NKT 激动剂）的局部给药。本发明还提供了一种使用细胞内渗透增强剂治疗癌症的方法。本发明的方法旨在杀死和/或消灭目标肿瘤细胞以及转移到身体其他部位的癌细胞。