3-amino-N-(3,4-dimethylphenyl)-4-methoxythieno[2,3-b]pyridine-2-carboxamide | 1097202-24-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-N-(3,4-dimethylphenyl)-4-methoxythieno[2,3-b]pyridine-2-carboxamide
• CAS: 1097202-24-8
• 化学式: C₁₇H₁₇N₃O₂S
• 分子量: 327.407
• InChiKey: RHDBURIBRRJQQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(3,4-dimethylphenyl)-2-mercaptoacetamide 、 2-溴-4-甲氧基吡啶-3-腈 在 potassium hydroxide 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以50%的产率得到3-amino-N-(3,4-dimethylphenyl)-4-methoxythieno[2,3-b]pyridine-2-carboxamide
  参考文献：
  名称：

  The Synthesis and Microbiological Activity of 2-Mercapto-4-methoxypyridine-3-carbonitrile Derivatives

  摘要：

  Synthesis of 2-(3-cyano-4-methoxypyridin-2-ylthio)acetic acid derivatives, starting either from 2-bromo-4-methoxypyridine-3-carbonitrile or 2-mercapto-4-methoxypyridine-3-carbonitrile is reported. The obtained products could be transformed by intramolecular Thorpe-Ziegler cyclization to related thieno[2,3-b]pyridines. Diazotization of 3-amino-N-(4-chlorophenyl)-4-methoxythieno[2,3-b]pyridine-2-carboxamide resulted in formation of a suitable pyridothienotriazine derivative. Some of the prepared compounds demonstrated noticeable bacteriostatic or tuberculostatic activity.

  DOI：

  10.3987/com-08-11439

文献信息

• The Synthesis and Microbiological Activity of 2-Mercapto-4-methoxypyridine-3-carbonitrile Derivatives
  作者：Agnieszka Miszke、Henryk Foks、Kamil Brożewicz、Anna Kędzia、Ewa Kwapisz、Zofia Zwolska

  DOI：10.3987/com-08-11439

  日期：——

  Synthesis of 2-(3-cyano-4-methoxypyridin-2-ylthio)acetic acid derivatives, starting either from 2-bromo-4-methoxypyridine-3-carbonitrile or 2-mercapto-4-methoxypyridine-3-carbonitrile is reported. The obtained products could be transformed by intramolecular Thorpe-Ziegler cyclization to related thieno[2,3-b]pyridines. Diazotization of 3-amino-N-(4-chlorophenyl)-4-methoxythieno[2,3-b]pyridine-2-carboxamide resulted in formation of a suitable pyridothienotriazine derivative. Some of the prepared compounds demonstrated noticeable bacteriostatic or tuberculostatic activity.