Methyl-4-chlorophenoxymethyl acetate, 2-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Methyl-4-chlorophenoxymethyl acetate, 2-
• 英文别名: (4-chloro-2-methylphenoxy)methyl acetate
• 化学式: C₁₀H₁₁ClO₃
• 分子量: 214.64
• InChiKey: PFCXBUSKOFXOJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• O-SUBSTITUTED HYDROXYARYL DERIVATIVES
  申请人：MUTO Susumu

  公开号：US20100113770A1

  公开（公告）日：2010-05-06

  A medicament having inhibitory activity against NF-κB activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in a main chain is 2 to 5 (said connecting group may be substituted), “A” represents an acyl group which may be substituted, (provided that unsubstituted acetyl group and unsubstituted acryloyl group are excluded,) or a C 1 to C 6 alkyl group which may be substituted, or A may bind to connecting group X to form a cyclic structure which may be substituted, “E” represents an aryl group which may be substituted or a heteroaryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

  一种具有抑制NF-κB活化活性的药物，其包括以下通式（I）所表示化合物或其药学上可接受的盐、水合物和溶剂化物作为活性成分，其中X表示主链中原子数为2到5的连接基（该连接基可以被取代），“A”表示可以被取代的酰基（不包括未取代的乙酰基和未取代的丙烯酰基）或者可以被取代的C1到C6烷基，或者A可以与连接基X结合形成可以被取代的环状结构，“E”表示可以被取代的芳基或者可以被取代的杂芳基，环Z表示可以具有一个或多个取代基的芳环，除了由公式-O-A所表示的基团外，还可以具有一个或多个取代基，其中A具有与上述定义相同的含义，由公式-X-E所表示的基团中，每个X和E具有与上述定义相同的含义，或者可以具有一个或多个取代基的杂芳环，其中A具有与上述定义相同的含义，由公式-X-E所表示的基团中，每个X和E具有与上述定义相同的含义。
• US7626042B2
  申请人：——

  公开号：US7626042B2

  公开（公告）日：2009-12-01