7-methylhexadec-6(E)-enoic acid | 18689-89-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-methylhexadec-6(E)-enoic acid
• 英文别名: 7-Methyl-6-hexadecenoic acid；(E)-7-methylhexadec-6-enoic acid
• CAS: 18689-89-9
• 化学式: C₁₇H₃₂O₂
• 分子量: 268.44
• InChiKey: DINXWFVSXJCVPK-JQIJEIRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethyl 7-methylhexadeca-2(E),6(E)-dienoate 在 氢氧化钾 、 magnesium 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 7-methylhexadec-6(E)-enoic acid
  参考文献：
  名称：

  7-甲基十六烷-6-烯酸的立体选择性合成，加勒比海海绵的一种成分

  摘要：

  摘要 以市售的甲基乙烯基酮为原料，首次合成了海洋天然产物(E)-7-甲基十六烷-6-烯酸(I)。其三取代烯烃部分的立体选择性生成是通过克莱森原酸酯重排完成的。

  DOI：

  10.1080/00397919208021115

文献信息

• LONG CHAIN FATTY ACID FORMULATIONS AND THEIR USE IN INHIBITING SALMONELLA INFECTION
  申请人：CORNELL UNIVERSITY

  公开号：US20200330420A1

  公开（公告）日：2020-10-22

  A method for inhibiting or preventing Salmonella invasion of the intestinal epithelium in a subject, the method comprising enterally administering to the subject a pharmaceutically effective amount of a fatty acid dissolved or suspended in a pharmaceutically acceptable carrier, wherein the fatty acid contains 10 to 30 carbon atoms, wherein the fatty acid is more particularly an unsaturated fatty acid containing 1-4 carbon-carbon double bonds and/or 1 or 2 carbon-carbon triple bonds, or the fatty acid is more particularly a cis-unsaturated fatty acid, or the fatty acid is more particularly a cis-2-unsaturated fatty acid having the formula: wherein n is an integer of 6-26, and the fatty acid optionally includes a second carbon-carbon double bond resulting from removal of two hydrogen atoms on adjacent carbon atoms.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING VIBRIO INFECTION<br/>[FR] COMPOSITIONS ET MÉTHODES D'INHIBITION D'UNE INFECTION PAR VIBRIO
  申请人：UNIV CORNELL

  公开号：WO2021202632A2

  公开（公告）日：2021-10-07

  Disclosed herein is a method for inhibiting or preventing Vibrio cholera toxin production in a subject, the method comprising enterally administering to the subject a pharmaceutically effective amount of a fatty acid dissolved or suspended in a pharmaceutically acceptable carrier, wherein the fatty acid contains 10 to 30 carbon atoms, such as an unsaturated fatty acid such as a cis-2-unsaturated fatty acid, such as a fatty acid having the formula (1) wherein n is an integer of 6-26, and the fatty acid optionally includes a second carbon-carbon double bond resulting from removal of two hydrogen atoms on adjacent carbon atoms. Also disclosed herein is a method for treating or preventing a Vibrio infection comprising administering to a subject in need of treatment an effective amount of a genetically engineered bacterium, wherein the genetically engineered bacterium comprises an exogenous nucleic acid encoding an enzyme that produces a diffusible signal factor (DSF) by introducing a cis-2 double bond to a fatty acid.
• Stereoselective Synthesis of 7-Methylhexadec-6-enoic Acid, a Component of Carribean Sponge
  作者：B. A. Kulkarni、A. Chattopadhyay、V. R. Mamdapur

  DOI：10.1080/00397919208021115

  日期：1992.11

  Abstract The marine natural product (E)-7-methyl hexadec-6-enoic acid(I), has been synthesised for the first time starting from commercially available methyl vinyl ketone. Stereoselective generation of its tri- substituted olefinic moiety is accomplished via Claisen orthoester rearrangement.

  摘要 以市售的甲基乙烯基酮为原料，首次合成了海洋天然产物(E)-7-甲基十六烷-6-烯酸(I)。其三取代烯烃部分的立体选择性生成是通过克莱森原酸酯重排完成的。