YAGFLR | 108524-90-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: YAGFLR
• 英文别名: Tyr-Ala-Gly-Phe-Leu-Arg-OH；H-Tyr-Ala-Gly-Phe-Leu-Arg-OH；(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
• CAS: 108524-90-9
• 化学式: C₃₅H₅₁N₉O₈
• 分子量: 725.845
• InChiKey: GDPHPXYFLPDZGH-OZDPOCAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  52
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  293
• 氢给体数：
  10
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  (2S)-5-(diaminomethylideneamino)-2-[[(2S)-4-methyl-2-[[(2S)-3-phenyl-2-[[2-[[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)-3-(4-phenylmethoxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]propanoyl]amino]pentanoyl]amino]pentanoic acid 生成 YAGFLR
  参考文献：
  名称：

  CHAZOV, E. I.;SMIRNOV, V. N.;VINOGRADOV, V. A.;TITOV, M. I.;PENIN, V. P.;+

  摘要：

  DOI：

文献信息

• HEXAPEPTID
  申请人：VSESOJUZNY KARDIOLOGICHESKY NAUCHNY TSENTR AKADEMII MEDITSINSKIKH NAUK SSSR

  公开号：EP0189485A1

  公开（公告）日：1986-08-06

  Hexapeptide having a Tyr-Ala-Gly-Phe-Leu-Arg structure and possessing antipancreanecrotic activity.

  具有 Tyr-Ala-Gly-Phe-Leu-Arg 结构的六肽，具有抗盘旋硬化活性。
• METHOD FOR IMMOBILISING BIOLOGICALLY ACTIVE SUBSTANCES ON POLYMER CARRIERS (VARIANTS) AND CONJUGATES PRODUCED BY SAID METHOD
  申请人：Scientific Future Management SFM

  公开号：EP2327777A1

  公开（公告）日：2011-06-01

  The invention relates to medicine, biology, pharmacology, in particular to a method for immobilizing a biologically active substance on a pharmacologically acceptable polymer carrier. The inventive method involves dissolving a biologically active substance in a polymer carrier aqueous solution, the concentration of which is greater than 0%, up to a saturated solution concentration and irradiating the reaction mixture by ionizing radiation. In order to protect the biologically active substance from being destroyed by ionizing radiation, the reaction mixture can be frozen at a temperature ranging from -20°C to -140°C prior to be irradiated. While being immobilized according to the inventive method, the biologically active substance is covalently linked to the polymer. The advantage of the inventive method consists in that it makes possible to immobilize on the polymer carrier those water-soluble biologically active substances which are unstable, i.e., which are destroyed totally or in part when immobilized by the other methods and to increase the portion of the preserved biologically active substance, when the biologically active substance is not totally destroyed during immobilization. The conjugate as a biologically active substance carrier is characterized in that the biologically active substance is selected from a group comprising proinsulin, tyrosyl-2-alanyl-glyceryl-phenylalanyl-leucyl-arginine diacetate, alcalase, hyaluronidase, somatotropin and in that the carrier is in the form of a pharmacologically acceptable water-soluble polymer which is selected from a group comprising polyethyleneoxide, polyvinylpirrolidone, dextran, pluronic and acrilamide, wherein a biologically active substance molecule is covalently linked to at least one polymer molecule.

  本发明涉及医学、生物学、药理学，尤其涉及一种将生物活性物质固定在药理学上可接受的聚合物载体上的方法。本发明的方法是将生物活性物质溶解在聚合物载体水溶液中，水溶液的浓度大于 0%，达到饱和溶液浓度，然后用电离辐射照射反应混合物。为了保护生物活性物质不被电离辐射破坏，可以在辐照前将反应混合物冷冻在-20℃至-140℃的温度范围内。根据本发明的方法进行固定时，生物活性物质与聚合物共价连接。本发明方法的优点在于，它可以将那些不稳定的水溶性生物活性物质固定在聚合物载体上，也就是说，在用其他方法固定时，这些生物活性物质会被完全或部分破坏。作为生物活性物质载体的共轭物的特征在于，生物活性物质选自包括脯胰岛素、酪氨酰-2-丙氨酰-甘油酰-苯丙氨酰-亮氨酰-精氨酸二乙酸酯、脂肪酶、透明质酸酶、其中生物活性物质分子与至少一个聚合物分子共价连接。
• US4695622A
  申请人：——

  公开号：US4695622A

  公开（公告）日：1987-09-22