2-Methyl-3-(4-methylpiperidine-1-carbonyl)benzo[f]benzofuran-4,9-quinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 2-Methyl-3-(4-methylpiperidine-1-carbonyl)benzo[f]benzofuran-4,9-quinone
• 英文别名: 2-methyl-3-(4-methylpiperidine-1-carbonyl)benzo[f][1]benzofuran-4,9-dione
• 化学式: C₂₀H₁₉NO₄
• 分子量: 337.4
• InChiKey: QOGGXHNNRVSSHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  67.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases
  申请人：Academia Sinica

  公开号：US11434229B2

  公开（公告）日：2022-09-06

  The present disclosure provides compounds of Formulas (I), (II), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating proliferative diseases, for example, cancer (e.g., lung cancer), and infectious diseases (e.g., bacterial infections).

  本公开提供了式(I)、(II)化合物及其药学上可接受的盐类。本文所述化合物可用于治疗增殖性疾病，例如癌症（如肺癌）和传染性疾病（如细菌感染）。
• METHOD FOR REGULATING SKIN PIGMENTATION
  申请人：Fisher David E.

  公开号：US20140296223A1

  公开（公告）日：2014-10-02

  This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation.
• 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES
  申请人：Academia Sinica

  公开号：US20200095233A1

  公开（公告）日：2020-03-26

  The present disclosure provides compounds of Formulas (I), (II), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating proliferative diseases, for example, cancer (e.g., lung cancer), and infectious diseases (e.g., bacterial infections).
• [EN] A METHOD FOR REGULATING SKIN PIGMENTATION<br/>[FR] PROCÉDÉ DE RÉGULATION DE LA PIGMENTATION DE LA PEAU
  申请人：GEN HOSPITAL CORP

  公开号：WO2013033520A1

  公开（公告）日：2013-03-07

  This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation.