7-benzyl-6-ethenyl-7H-purine | 199170-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-benzyl-6-ethenyl-7H-purine
• 英文别名: 7-Benzyl-6-ethenylpurine
• CAS: 199170-74-6
• 化学式: C₁₄H₁₂N₄
• 分子量: 236.276
• InChiKey: YACBVBOSTAECAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  苯硫酚 、 7-benzyl-6-ethenyl-7H-purine 在 camphor-10-sulfonic acid 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 3.0h， 以36%的产率得到7-benzyl-6-(2-phenylthioethyl)-7H-purine
  参考文献：
  名称：

  Addition of Nucleophiles to 6-Vinylpurines.

  摘要：

  6-Vinylpurines readily participate in nucleophilic addition reactions. Treatment with sodium salts of alcohols and thiols, as well as stabilised carbanions, results in clean conversion into a variety of functionalized purine derivatives. Additions performed in the presence of acid give 1 : 1 adducts together with dimeric purine products. Under acidic conditions the adduct first formed reacts further with another molecule of vinylpurine.

  DOI：

  10.3891/acta.chem.scand.51-1116
• 作为产物：
  描述：

  三丁基乙烯基锡 、 7-苯基-6-氯-7H-嘌呤 在 bis(triphenylphosphine)palladium(II)-chloride 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 以90%的产率得到7-benzyl-6-ethenyl-7H-purine
  参考文献：
  名称：

  Addition of Nucleophiles to 6-Vinylpurines.

  摘要：

  6-Vinylpurines readily participate in nucleophilic addition reactions. Treatment with sodium salts of alcohols and thiols, as well as stabilised carbanions, results in clean conversion into a variety of functionalized purine derivatives. Additions performed in the presence of acid give 1 : 1 adducts together with dimeric purine products. Under acidic conditions the adduct first formed reacts further with another molecule of vinylpurine.

  DOI：

  10.3891/acta.chem.scand.51-1116

文献信息

• Addition of Nucleophiles to 6-Vinylpurines.
  作者：Anniken T. Øverås、Anne Kristin Bakkestuen、Lise-Lotte Gundersen、Frode Rise、Michael P. Hartshorn、Manuela Merchán、Ward T. Robinson、Björn O. Roos、Claire Vallance、Bryan R. Wood

  DOI：10.3891/acta.chem.scand.51-1116

  日期：——

  6-Vinylpurines readily participate in nucleophilic addition reactions. Treatment with sodium salts of alcohols and thiols, as well as stabilised carbanions, results in clean conversion into a variety of functionalized purine derivatives. Additions performed in the presence of acid give 1 : 1 adducts together with dimeric purine products. Under acidic conditions the adduct first formed reacts further with another molecule of vinylpurine.