1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranose

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-alpha-D-galactopyranose
• 英文别名: (3,4,6-triacetyloxy-5-azidooxan-2-yl)methyl acetate
• 化学式: C14H19N3O9
• 分子量: 373.32
• InChiKey: QKGHBQJLEHAMKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• SACCHARIDE STRUCTURES AND METHODS OF MAKING AND USING SUCH STRUCTURES
  申请人：Roy Sucharita

  公开号：US20110201801A1

  公开（公告）日：2011-08-18

  Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also described.

  描述了具有保护基团的寡糖，该保护基团位于适于衍生的寡糖的两个、多个、大多数或每个位置。还描述了此类寡糖的集合、库以及制造和使用方法。
• Synthetic oligomers of Neisseria meningitis serogroup X and process of preparing them
  申请人：MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.

  公开号：US10183962B2

  公开（公告）日：2019-01-22

  The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinafter Men-X), more particularly tetramer. The present invention provides Men-X capsular oligomers obtained from synthetic pathway using purified saccharides of specific chain length and provides said novel oligomers as candidates for the development of conjugate vaccine against bacterial meningitis caused due to Men-X infections.

  本发明涉及新型高级低聚物的合成及其制备工艺。特别是本发明涉及脑膜炎奈瑟菌血清群 X（以下简称 Men-X）的低聚物，尤其是四聚体的化学合成。本发明提供了利用特定链长的纯化糖通过合成途径获得的 Men-X 荚膜低聚物，并提供了上述新型低聚物作为候选物，用于开发预防由 Men-X 感染引起的细菌性脑膜炎的结合疫苗。
• NOVEL SYNTHETIC OLIGOMERS OF NEISSERIA MENINGITIS SEROGROUP X AND PROCESS OF PREPARING THEM
  申请人：Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd.

  公开号：EP3110825B1

  公开（公告）日：2020-12-09
• US7244712B2
  申请人：——

  公开号：US7244712B2

  公开（公告）日：2007-07-17
• US9163047B2
  申请人：——

  公开号：US9163047B2

  公开（公告）日：2015-10-20