Styrylsulfonylacetic acid | 102154-41-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Styrylsulfonylacetic acid
• 英文别名: 2-(2-phenylethenylsulfonyl)acetic acid
• CAS: 102154-41-6
• 化学式: C₁₀H₁₀O₄S
• mdl: MFCD00068079
• 分子量: 226.25
• InChiKey: WCOXFTGMNJJABC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  4-phenylbut-3-enethioic S-acid 、 Styrylsulfonylacetic acid 、 在 水 作用下， 以 溶剂黄146 、 双氧水 为溶剂， 反应 1.0h， 生成 (Z)-β-styrylsulfonylacetic acid
  参考文献：
  名称：

  Styryl sulfone anticancer agents

  摘要：

  本发明的苯基磺酮化合物可以选择性地抑制肿瘤细胞的增殖，并诱导肿瘤细胞凋亡，同时不影响正常细胞。该化合物可用于治疗癌症和其他增生性疾病，其具有以下特征： （a）公式II：其中n为零或一；R1选自氢、氯、氟和溴的群组；R2选自氢、氯、氟、溴、甲基和甲氧基的群组；R3选自氢、氯和氟的群组；但当R1和R3均为氢且n为零或一时，R2不能为甲基或甲氧基；当n为一时，R1、R2和R3不能全为氢。 （b）公式III：其中R1选自氢、氯、氟和溴的群组； （c）公式IV：其中R1选自氟和溴的群组，R2选自2-氯苯基、4-氯苯基、4-氟苯基和2-硝基苯基的群组。

  公开号：

  US20030114538A1

文献信息

• Styryl sulfone anticancer agents
  申请人：——

  公开号：US20020022666A1

  公开（公告）日：2002-02-21

  Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have (a) the formula II: 1 wherein n is zero or one; R 1 is selected from the group consisting of hydrogen, chlorine, fluorine and bromine; R 2 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, methyl and methoxy; and R 3 is selected from the group consisting of hydrogen, chlorine and fluorine; provided, R 2 may not be methyl or methoxy when R 1 and R 3 are both hydrogen and n is zero or one; and R 1 , R 2 and R 3 may not all be hydrogen when n is one; (b) the formula III: 2 wherein R 1 is selected from the group consisting of hydrogen, chlorine, fluorine and bromine; or (c) or the formula IV: 3 wherein R 1 is selected from the group consisting of fluorine and bromine, and R 2 is selected from the group consisting of 2-chlorophenyl, 4-chlorophenyl, 4-fluorophenyl and 2-nitrophenyl.

  本发明的苯基磺酮化合物选择性抑制肿瘤细胞增殖，诱导肿瘤细胞凋亡，同时不影响正常细胞。这些化合物在治疗癌症和其他增生性疾病中有用，包括： （a）式II：其中n为零或一；R1选自氢、氯、氟和溴的群；R2选自氢、氯、氟、溴、甲基和甲氧基的群；R3选自氢、氯和氟的群；但是，当R1和R3均为氢且n为零或一时，R2不能为甲基或甲氧基；当n为一时，R1、R2和R3不能都为氢。 （b）式III：其中R1选自氢、氯、氟和溴的群；或 （c）式IV：其中R1选自氟和溴的群，R2选自2-氯苯基、4-氯苯基、4-氟苯基和2-硝基苯基的群。
• Method for protecting cells and tissues from ionizing radiation toxicity with alpha, beta unsaturated aryl sulfones
  申请人：——

  公开号：US20030060505A1

  公开（公告）日：2003-03-27

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective &agr;,&bgr; unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of &agr;,&bgr; unsaturated arylsulfone.

  预处理使用α，β不饱和芳基磺酮可以保护正常细胞免受电离辐射的毒副作用。在抗癌放疗之前向患者给予放射性保护α，β不饱和芳基磺酮化合物可以减少辐射对正常细胞的细胞毒性副作用。α，β不饱和芳基磺酮的辐射保护效果可以让临床医生安全地增加抗癌放射剂量。在某些情况下，无意中接触辐射后毒性的缓解可以通过给予α，β不饱和芳基磺酮来缓解。
• (E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
  申请人：——

  公开号：US20030149109A1

  公开（公告）日：2003-08-07

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

  使用α，β不饱和芳基磺酮进行预处理，可以保护正常细胞免受两类抗癌化疗药物的细胞毒性副作用。在使用有丝分裂期细胞周期抑制剂或拓扑异构酶抑制剂进行抗癌化疗前向患者给予细胞保护性磺酮化合物，可以减少或消除抗癌药物对正常细胞的细胞毒性副作用。α，β不饱和芳基磺酮的细胞保护作用使临床医生能够安全地增加抗癌化疗剂量。
• Method for protecting cells and tissues from ionizing radiation toxicity with &agr;, &bgr; unsaturated aryl sulfones
  申请人：Temple University - Of The Commonwealth System of Higher Education

  公开号：US06667346B2

  公开（公告）日：2003-12-23

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective &agr;,&bgr; unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of &agr;,&bgr; unsaturated arylsulfone.

  使用α，β不饱和芳基磺酮预处理可以保护正常细胞免受电离辐射的毒性副作用。在抗癌放疗之前向患者给予放射保护性α，β不饱和芳基磺酮化合物，可以减少辐射对正常细胞的细胞毒性副作用。α，β不饱和芳基磺酮的辐射保护作用使临床医生可以安全地增加抗癌放疗的剂量。在某些情况下，通过给予α，β不饱和芳基磺酮可以缓解意外辐射暴露后的毒性作用。
• Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
  申请人：——

  公开号：US20040214903A1

  公开（公告）日：2004-10-28

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

  预处理使用α，β不饱和芳基磺酮可以保护正常细胞免受两类抗癌化疗药物的细胞毒副作用。在使用有丝分裂期细胞周期抑制剂或拓扑异构酶抑制剂的抗癌化疗前向患者给予细胞保护性磺酮化合物，可以减少或消除抗癌药物对正常细胞的细胞毒副作用。α，β不饱和芳基磺酮的细胞保护作用使临床医生可以安全地增加抗癌化疗药物的剂量。