(3-Benzyloxycarbonylamino-hexa-4,5-dienyl)-phosphonic acid diethyl ester | 443307-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Benzyloxycarbonylamino-hexa-4,5-dienyl)-phosphonic acid diethyl ester
• CAS: 443307-01-5
• 化学式: C₁₈H₂₆NO₅P
• 分子量: 367.382
• InChiKey: MKBXEDRMZVOIRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3-Benzyloxycarbonylamino-hexa-4,5-dienyl)-phosphonic acid diethyl ester 在 重铬酸吡啶 、 臭氧 作用下， 以 二氯甲烷 为溶剂， 生成 Z-Abu(PO3Et2)-OH
  参考文献：
  名称：

  A convenient procedure for the preparation of α-aminoallenes using a three-component reaction of aldehyde, carbamate and propargylsilane

  摘要：

  A three-component reaction is described using an aldehyde, a carbamate and trimethylpropargylsilane in the presence of a Lewis acid for the production in moderate to good yield of alpha-allenyl amines. The reaction is applicable to aromatic or aliphatic aldehydes, The obtained alpha-aminoallenes are transformed into Delta(3)-pyrrolidines or amino acids by Using the reactivity of the cumulene function. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00056-4
• 作为产物：
  描述：

  diethyl (3-oxopropyl)phosphonate 、 氨基甲酸苄酯 、 炔丙基三甲基硅烷 在 三氟化硼乙醚 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以77%的产率得到(3-Benzyloxycarbonylamino-hexa-4,5-dienyl)-phosphonic acid diethyl ester
  参考文献：
  名称：

  A convenient procedure for the preparation of α-aminoallenes using a three-component reaction of aldehyde, carbamate and propargylsilane

  摘要：

  A three-component reaction is described using an aldehyde, a carbamate and trimethylpropargylsilane in the presence of a Lewis acid for the production in moderate to good yield of alpha-allenyl amines. The reaction is applicable to aromatic or aliphatic aldehydes, The obtained alpha-aminoallenes are transformed into Delta(3)-pyrrolidines or amino acids by Using the reactivity of the cumulene function. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00056-4

文献信息

• A convenient procedure for the preparation of α-aminoallenes using a three-component reaction of aldehyde, carbamate and propargylsilane
  作者：Manuella Billet、Angèle Schoenfelder、Philippe Klotz、André Mann

  DOI：10.1016/s0040-4039(02)00056-4

  日期：2002.2

  A three-component reaction is described using an aldehyde, a carbamate and trimethylpropargylsilane in the presence of a Lewis acid for the production in moderate to good yield of alpha-allenyl amines. The reaction is applicable to aromatic or aliphatic aldehydes, The obtained alpha-aminoallenes are transformed into Delta(3)-pyrrolidines or amino acids by Using the reactivity of the cumulene function. (C) 2002 Elsevier Science Ltd. All rights reserved.