1-Amino-4-(β-hydroxyethylamino)anthrachinon | 4859-56-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-Amino-4-(β-hydroxyethylamino)anthrachinon
• 英文别名: 1-amino-4-(2-hydroxy-ethylamino)-anthraquinone；1-Amino-4-(2-hydroxy-aethylamino)-anthrachinon；1-Amino-4-(2-hydroxyethylamino)anthracene-9,10-dione
• CAS: 4859-56-7
• 化学式: C₁₆H₁₄N₂O₃
• 分子量: 282.299
• InChiKey: JGROUZTXGGAILH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sodium 1-amino-4-bromoanthraquinone-2-sulfonate 在 硫酸 、 copper(I) bromide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 1-Amino-4-(β-hydroxyethylamino)anthrachinon
  参考文献：
  名称：

  卤代蒽醌衍生物与胺在质子惰性溶剂中的乌尔曼缩合反应

  摘要：

  在非质子介质中卤代蒽醌与胺的乌尔曼缩合反应中，亚铜催化剂比铜催化剂更有效。在 Cu(I) 催化剂存在下，具有羟基的胺（3-氨基-1-丙醇和 2-氨基乙醇）比碱性更高的丁胺更具反应性。

  DOI：

  10.1246/bcsj.50.547

文献信息

• Anthraquinone quencher dyes, their methods of preparation and use
  申请人：INTEGRATED DNA TECHNOLOGIES, INC.

  公开号：EP2281798A1

  公开（公告）日：2011-02-09

  The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.

  本发明提供了可用作广谱荧光淬灭剂的新型蒽醌组合物，并提供了制造和使用它们的方法。蒽醌淬灭剂可与多种生物相关化合物共轭，包括脂质、核酸、多肽，更具体地说是抗原、类固醇、维生素、药物、催化剂、代谢物、毒素、环境污染物、氨基酸、肽、蛋白质、核苷酸、寡核苷酸、多核苷酸、碳水化合物及其类似物。本发明还提供了包含在一个或多个容器中的至少一种本发明蒽醌淬灭染料组合物的试剂盒，以及该组合物的使用说明。
• Bansho, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1952, vol. 55, p. 666,668
  作者：Bansho

  DOI：——

  日期：——
• Naiki, Yuki Gosei Kagaku Kyokaishi, 1954, vol. 12, p. 401,403
  作者：Naiki

  DOI：——

  日期：——
• METHOD OF DETECTING FLUORESCENCE
  申请人：Laikhter Andrei

  公开号：US20110060150A1

  公开（公告）日：2011-03-10

  The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.
• US3971740A
  申请人：——

  公开号：US3971740A

  公开（公告）日：1976-07-27