5Z,8Z,11E,14E-eicosatetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5Z,8Z,11E,14E-eicosatetraenoic acid
• 英文别名: (5Z,8Z,11E,14E)-icosa-5,8,11,14-tetraenoic acid
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: YZXBAPSDXZZRGB-BJCBFJDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] METHODS OF PREPARING FREE POLYUNSATURATED FATTY ACIDS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ACIDES GRAS POLYINSATURÉS LIBRES
  申请人：MARTEK BIOSCIENCES CORP

  公开号：WO2012112902A1

  公开（公告）日：2012-08-23

  Provided herein are methods of making compositions of free fatty acids and alkyl esters of polyunsaturated fatty acids (PUFAs). Also provided are compositions comprising a PUFA selected from a free fatty acid or a ester wherein the PUFA is made according to a method of the invention.

  本文提供了制备自由脂肪酸和多不饱和脂肪酸（PUFAs）的烷基酯的方法。还提供了包含PUFA的组合物，所述PUFA选自自由脂肪酸或酯，其中PUFA是根据本发明的方法制备的。
• MICROBIAL OIL, METHOD FOR MANUFACTURING MICROBIAL OIL, CONCENTRATED MICROBIAL OIL, AND METHOD FOR MANUFACTURING CONCENTRATED MICROBIAL OIL
  申请人：Nippon Suisan Kaisha, Ltd.

  公开号：EP3101138A1

  公开（公告）日：2016-12-07

  A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

  一种微生物油，包含：一定量的以脂肪酸烷基酯形式和/或以游离脂肪酸形式存在的至少一种多不饱和脂肪酸，其碳原子数至少为 20；以及一定量的以脂肪酸烷基酯形式和/或以游离脂肪酸形式存在的热产脂肪酸，其碳原子数为 16 至 22。一种生产方法，包括：提供含有至少一种多不饱和脂肪酸的起始油，该脂肪酸以烷基酯和/或游离脂肪酸的形式至少具有 20 个碳原子，该脂肪酸从微生物生物质中获得；在特定条件下对起始油进行精馏；获得上述微生物油。利用上述生产方法获得的浓缩微生物油及其生产方法。一种用于治疗或预防炎症性疾病的制剂，包含上述微生物油或浓缩微生物油。
• MICROBIAL OIL, PRODUCTION METHOD FOR MICROBIAL OIL, CONCENTRATED MICROBIAL OIL, AND PRODUCTION METHOD FOR CONCENTRATED MICROBIAL OIL
  申请人：NIPPON SUISAN KAISHA, LTD.

  公开号：EP3900543A1

  公开（公告）日：2021-10-27

  A microbial oil comprises dihomo-γ-linolenic acid in fatty acid alkyl ester form and/or in free fatty acid form at a content of at least 50% by weight of the total weight of fatty acids in the oil. The content of thermally-produced fatty acid having from 16 to 22 carbon atoms, generated by heat associated with distillation in the production method, is from 0.0001% by weight to 3.0% by weight of the total weight of fatty acids in the microbial oil. A production method thereof comprises providing a starting oil containing dihomo-γ-linolenic acid in alkyl ester form and/or a free fatty acid form, obtained from microbial biomass; performing rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. Other aspects are a concentrated microbial oil, and use of the described oils as an agent for treating or preventing inflammatory disease.

  一种微生物油包含脂肪酸烷基酯形式和/或游离脂肪酸形式的二氢-γ-亚麻酸，其含量至少占油中脂肪酸总重量的 50%（按重量计）。在生产方法中，通过蒸馏产生的热量产生的具有 16 至 22 个碳原子的脂肪酸的含量占微生物油中脂肪酸总重量的 0.0001%（按重量计）至 3.0%（按重量计）。其生产方法包括提供从微生物生物质中获得的含有烷基酯形式和/或游离脂肪酸形式的二氢-γ-亚麻酸的起始油；在特定条件下对起始油进行精馏；获得上述微生物油。其他方面是浓缩微生物油，以及将所述油用作治疗或预防炎症疾病的制剂。
• Prophylaxis and treatment of preterm birth associated bronchopulmonary dysplasia (BPD)
  申请人：Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet

  公开号：US10898454B2

  公开（公告）日：2021-01-26

  A composition for the prophylaxis and/or treatment of a developmental disorder which is associated with preterm birth, and a method for the diagnosis and/or determination and/or prediction of the degree of severity of a developmental disorder which is associated with preterm birth.

  一种用于预防和/或治疗与早产有关的发育障碍的组合物，以及一种用于诊断和/或确定和/或预测与早产有关的发育障碍严重程度的方法。
• Microbial oil, production method for microbial oil, concentrated microbial oil, and production method for concentrated microbial oil
  申请人：NIPPON SUISAN KAISHA, LTD.

  公开号：US11330817B2

  公开（公告）日：2022-05-17

  A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

  一种微生物油，包含：一定量的以脂肪酸烷基酯形式和/或以游离脂肪酸形式存在的至少一种多不饱和脂肪酸，其碳原子数至少为 20；以及一定量的以脂肪酸烷基酯形式和/或以游离脂肪酸形式存在的热产脂肪酸，其碳原子数为 16 至 22。一种生产方法，包括：提供含有至少一种多不饱和脂肪酸的起始油，该脂肪酸以烷基酯和/或游离脂肪酸的形式至少具有 20 个碳原子，该脂肪酸从微生物生物质中获得；在特定条件下对起始油进行精馏；获得上述微生物油。利用上述生产方法获得的浓缩微生物油及其生产方法。一种用于治疗或预防炎症性疾病的制剂，包含上述微生物油或浓缩微生物油。