4-chloro-6-(o-tolyl)pyrimidin-2-amine | 862168-08-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-chloro-6-(o-tolyl)pyrimidin-2-amine
• 英文别名: 4-chloro-6-(2-methylphenyl)pyrimidin-2-amine
• CAS: 862168-08-9
• 化学式: C₁₁H₁₀ClN₃
• 分子量: 219.673
• InChiKey: XSKALECPQJXNSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-chloro-6-(o-tolyl)pyrimidin-2-amine 在 N,O-双三甲硅基乙酰胺 作用下， 以 正丁醇 为溶剂， 生成 2-Furan-2-yl-7-o-tolyl-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
  参考文献：
  名称：

  2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1

  摘要：

  The structure-activity relationship of this novel class of compounds based on 2-(2-furanyl)-7-phenyl[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, 1, and its analogs was evaluated for their in vitro and in vivo adenosine A(2A) receptor antagonism. Several compounds displayed oral activity at 3 mg/kg in a rat catalepsy model. Specifically, compound 8g displayed an excellent in vitro profile, as well as a highly promising in vivo profile. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.086
• 作为产物：
  描述：

  2-氨基-4,6-二氯嘧啶 、 2-甲基苯硼酸 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 4-chloro-6-(o-tolyl)pyrimidin-2-amine
  参考文献：
  名称：

  2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1

  摘要：

  The structure-activity relationship of this novel class of compounds based on 2-(2-furanyl)-7-phenyl[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, 1, and its analogs was evaluated for their in vitro and in vivo adenosine A(2A) receptor antagonism. Several compounds displayed oral activity at 3 mg/kg in a rat catalepsy model. Specifically, compound 8g displayed an excellent in vitro profile, as well as a highly promising in vivo profile. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.086

文献信息

• Pyrimidine Derivatives As HSP90 Inhibitors
  申请人：Chessari Gianni

  公开号：US20090215777A1

  公开（公告）日：2009-08-27

  The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates or N-oxides thereof; wherein: A is N or a group CR 3 ; R 1 is a monocyclic or bicyclic carbocyclic or heterocyclic ring of 5 to 10 ring members of which up to two ring members may be heteroatoms selected from N, O and S and the remainder are carbon atoms, the carbocyclic or heterocyclic ring being optionally substituted by one or more substituent groups independently selected from R 10 ; and R 2 , R 3 and R 10 are as defined in the claims.

  该发明提供了一种化合物，用作Hsp90的抑制剂，该化合物具有以下式（I）：或其盐、互变异构体、溶剂合物或N-氧化物；其中：A为N或CR基团；R1为由5至10个环成员组成的单环或双环碳环或杂环，其中最多两个环成员可以是从N、O和S中选择的杂原子，其余为碳原子，碳环或杂环可以选择地被一个或多个取代基独立地选择自R10的取代基取代；而R2、R3和R10如权利要求中所定义。
• [EN] MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR<br/>[FR] MODULATEURS DU RÉGULATEUR DE LA CONDUCTANCE TRANSMEMBRANAIRE DE LA MUCOVISCIDOSE
  申请人：VERTEX PHARMA

  公开号：WO2022076625A1

  公开（公告）日：2022-04-14

  This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

  本发明提供了囊性纤维化跨膜传导调节因子（CFTR）的调节剂，其具有核心结构（I），包含至少一种这样的调节剂的制药组合物，使用这样的调节剂和制药组合物治疗CFTR介导的疾病，包括囊性纤维化，组合制药组合物和组合疗法，以及制造这样的调节剂的过程和中间体。
• Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A_2A Receptor Antagonists for Cancer Immunotherapy
  作者：Chenyu Zhu、Shuyin Ze、Ronghui Zhou、Xinyu Yang、Haojie Wang、Xiaolei Chai、Meimiao Fang、Mingyao Liu、Yonghui Wang、Weiqiang Lu、Qiong Xie

  DOI：10.1021/acs.jmedchem.2c01860

  日期：——

  of adenosine A2A receptor (A2AR) antagonists as novel approaches for cancer immunotherapy. By screening our in-house compound library, a pyridinone hit compound (1) with weak A2AR antagonistic activity was identified. Further structure–activity relationship studies revealed a series of pyridinone derivatives with strong potency. Compound 38 stood out with a potent A2AR antagonistic activity (IC50 =

  最近的研究和临床证据强烈支持开发腺苷 A 2A受体 (A 2A R) 拮抗剂作为癌症免疫治疗的新方法。通过筛选我们的内部化合物库，鉴定出具有弱 A 2A R 拮抗活性的吡啶酮命中化合物 ( 1 ) 。进一步的构效关系研究揭示了一系列具有强大效力的吡啶酮衍生物。化合物38具有强大的 A 2A R 拮抗活性（IC 50 = 29.0 nM）、良好的小鼠肝微粒体代谢稳定性（t 1/2 = 86.1 分钟）和出色的口服生物利用度（F= 86.1%)。值得注意的是，38通过下调免疫抑制分子（LAG-3和TIM-3）和上调效应分子（GZMB、IFNG和IL-2）有效增强了体外 T 细胞的激活和杀伤能力。此外，38在 MC38 肿瘤模型中通过口服给药表现出优异的体内抗肿瘤活性，肿瘤生长抑制 (TGI) 为 56.0%，证明其作为癌症免疫治疗的新型 A 2A R 拮抗剂候选物的潜力。
• PYRIMIDINE DERIVATIVES AS HSP90 INHIBITORS
  申请人：Astex Therapeutics Limited

  公开号：EP2049497A2

  公开（公告）日：2009-04-22
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES
  申请人：ASTEX THERAPEUTICS LTD

  公开号：WO2006123165A2

  公开（公告）日：2006-11-23

  [EN] The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates or N-oxides thereof; wherein: A is N or a group CR³; R¹ is a monocyclic or bicyclic carbocyclic or heterocyclic ring of 5 to 10 ring members of which up to two ring members may be heteroatoms selected from N, O and S and the remainder are carbon atoms, the carbocyclic or heterocyclic ring being optionally substituted by one or more substituent groups independently selected from R¹⁰; and R², R³ and R¹⁰ are as defined in the claims.
  [FR] La présente invention concerne un composé inhibiteur de Hsp90 représenté par la formule générale (I), l'un de ses sels, tautomères, solvats ou N-oxydes. Dans cette formule, A est N ou un groupe CR³. R¹ est un noyau monocyclique ou bicyclique, carbocyclique ou hétérocyclique portant de 5 à 10 segments dont deux au maximum peuvent être hétéroatomes choisis parmi N, O et S, le reste étant des atomes de carbone. Le noyau carbocyclique ou hétérocyclique est éventuellement substitué par un ou plusieurs groupes substituants choisis indépendamment parmi R¹⁰. R², R³ et R¹⁰ sont tels que définis dans les revendications.