1-Hexadecanoyl-4-hydroxypyrrolidine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Hexadecanoyl-4-hydroxypyrrolidine-2-carboxylic acid
• 化学式: C₂₁H₃₉NO₄
• 分子量: 369.5
• InChiKey: SRHSPJGTSWHUTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Antimicrobial compositions
  申请人：SYMRISE AG

  公开号：US11116710B2

  公开（公告）日：2021-09-14

  The present invention is the use of a compound of formula (I) or a (pharmaceutically) acceptable salt thereof, wherein (a) X denotes CH═CH or CZ1=CZ2, wherein if Z1 is H then Z2 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt and if Z2 is H then Z1 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH, wherein n is 2 to 5 and R denotes a radical selected from the group consisting of H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt and NEt2, or (b) X denotes O, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH and OMe, wherein n is 2 to 5 and R denotes H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt, NEt2 as antimicrobial agent as well as to composition comprising said agent.

  本发明是式(I)化合物或其(药学上)可接受的盐的用途，其中(a) X表示CH═CH或CZ1=CZ2，如果Z1是H，则Z2表示选自由OH、NH2、NHMe、NMe2、OMe和OEt组成的组的基，如果Z2是H，则Z1表示选自由OH、NH2、NHMe2、OMe和OEt组成的组的基、NH2、NHMe、NMe2、OMe 和 OEt 所组成的组中的基，如果 Z2 是 H，则 Z1 表示选自 OH、NH2、NHMe、NMe2、OMe 和 OEt 所组成的组中的基，Y 表示选自 NH2、NHMe、其中 n 为 2 至 5，R 表示选自由 H、OH、Me、Et、OMe、OEt、NH2、NHMe、NMe2、NHEt 和 NEt2 组成的基团，或 (b) X 表示 O，Y 表示选自由 NH2、NHMe、NMe2、OMe 和 OEt 组成的基团、NHMe、NMe2、NHEt、O-(CH2)n-OH 和 OMe，其中 n 为 2 至 5，R 表示 H、OH、Me、Et、OMe、OEt、NH2、NHMe、NMe2、NHEt、NEt2。
• COSMETIC COMPOSITIONS
  申请人：Symrise AG

  公开号：US20150190326A1

  公开（公告）日：2015-07-09

  Suggested is a cosmetic composition, comprising (a) menthone compounds according to formula (Ia) or (Ib) and (b) at least one oil body or wax, and optionally (c) at least one emulsifier and/or (d) at least one active principle.
• ANTIMICROBIAL COMPOSITIONS
  申请人：SYMRISE AG

  公开号：US20190282478A1

  公开（公告）日：2019-09-19

  The present invention is the use of a compound of formula (I) or a (pharmaceutically) acceptable salt thereof, wherein (a) X denotes CH═CH or CZ1=CZ2, wherein if Z1 is H then Z2 denotes a radical selected from the group consisting of OH, NH 2 , NHMe, NMe 2 , OMe and OEt and if Z2 is H then Z1 denotes a radical selected from the group consisting of OH, NH 2 , NHMe, NMe 2 , OMe and OEt, Y denotes a radical selected from the group consisting of NH 2 , NHMe, NMe 2 , NHEt, O—(CH 2 ) n —OH, wherein n is 2 to 5 and R denotes a radical selected from the group consisting of H, OH, Me, Et, OMe, OEt, NH 2 , NHMe, NMe 2 , NHEt and NEt 2 , or (b) X denotes O, Y denotes a radical selected from the group consisting of NH 2 , NHMe, NMe 2 , NHEt, O—(CH 2 ) n —OH and OMe, wherein n is 2 to 5 and R denotes H, OH, Me, Et, OMe, OEt, NH 2 , NHMe, NMe 2 , NHEt, NEt 2 as anti-microbial agent as well as to composition comprising said agent.