4-(2-azidoethoxy)-4-oxobutanoic acid | 1104858-31-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(2-azidoethoxy)-4-oxobutanoic acid
• 英文别名: 4-(2-Azidoethoxy)-4-oxobutanoic Acid
• CAS: 1104858-31-2
• 化学式: C₆H₉N₃O₄
• 分子量: 187.155
• InChiKey: KTJSCZONNCGLNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 2-叠氮基乙醇 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以84%的产率得到4-(2-azidoethoxy)-4-oxobutanoic acid
  参考文献：
  名称：

  一种基于石墨烯/量子点纳米复合物的新型信号开启式光电化学生物传感器，该复合物通过Bipyridinium Relay和AuNPs的双重猝灭效应进行了放大

  摘要：

  通过使用羧基官能化的石墨烯和CdSe纳米粒子，开发了一种新型的光电化学（PEC）生物传感器。该灵敏的界面随后基于PEC纳米粒子的双猝灭效应成功地应用于凝血酶的检测，PEC纳米粒子依赖于双吡啶继电器的电子转移和AuNPs的能量转移。用适体识别后，将PEC纳米颗粒去除，并获得一个信号信号PEC生物传感器。此外，用于制备PEC纳米粒子的生物条形码技术可以避免交叉反应并提高灵敏度。利用上述各种方法的优点，可以容易地提高灵敏度。此外，在这项工作中，我们还研究了用不同官能团和不同粒径的AuNPs改性的石墨烯。-15 中号达到了。由于其简单，选择性和灵敏性，该策略显示了制造高效PEC生物传感器的巨大希望。

  DOI：

  10.1002/chem.201202213

文献信息

• Process for producing chemically functionalized nano graphene materials
  申请人：Zhamu Aruna

  公开号：US20130005917A1

  公开（公告）日：2013-01-03

  Provided in this invention is a process for producing chemically functionalized nano graphene materials, known as nano graphene platelets (NGPs), graphene nano sheets, or graphene nano ribbons. Subsequently, a polymer can be grafted to a functional group of the resulting functionalized graphene. In one preferred embodiment, the process comprises a step of mixing a starting nano graphene material having edges and two primary graphene surfaces, an azide or bi-radical compound, and an organic solvent in a reactor, and allowing a chemical reaction between the nano graphene material and the azide compound to proceed at a temperature for a length of time sufficient to produce the functionalized nano graphene material.

  本发明提供了一种生产化学功能化纳米石墨烯材料的方法，被称为纳米石墨烯片（NGPs）、石墨烯纳米片或石墨烯纳米带。随后，可以将聚合物嫁接到所得到的功能化石墨烯的功能基上。在一种首选实施方案中，该过程包括将具有边缘和两个主要石墨烯表面的起始纳米石墨烯材料、叠氮化合物或双自由基化合物以及有机溶剂混合在反应器中，并允许在足够时间和温度下进行纳米石墨烯材料和叠氮化合物之间的化学反应，以产生功能化的纳米石墨烯材料。
• Production of chemically functionalized nano graphene materials
  申请人：Nanotek Instruments, Inc.

  公开号：US08287699B2

  公开（公告）日：2012-10-16

  Provided in this invention is a process for producing chemically functionalized nano graphene materials, known as nano graphene platelets (NGPs), graphene nano sheets, or graphene nano ribbons. Subsequently, a polymer can be grafted to a functional group of the resulting functionalized NGPs. In one preferred embodiment, the process comprises (A) dispersing a pristine graphite material and an azide or bi-radical compound in a liquid medium comprising to form a suspension; and (B) subjecting the suspension to direct ultrasonication with to ultrasonic waves of a desired intensity or power level for a length of time sufficient to produce nano graphene platelets and to enable a chemical reaction to occur between the nano graphene platelets and the azide or bi-radical compound to produce the functionalized nano graphene material. Concurrent production and functionalization of NGPs directly from pristine graphitic materials can be achieved in one step and in the same reactor.

  本发明提供了一种生产化学功能化纳米石墨烯材料的方法，称为纳米石墨烯片（NGPs），石墨烯纳米片或石墨烯纳米带。随后，可以将聚合物嫁接到所得到的功能化NGPs的功能基上。在一种首选实施例中，该方法包括（A）将原始石墨材料和叠氮化物或双自由基化合物分散在液体介质中形成悬浮液；以及（B）将悬浮液暴露于所需强度或功率水平的超声波下，超声波的长度足以产生纳米石墨烯片并使纳米石墨烯片与叠氮化物或双自由基化合物之间发生化学反应以产生功能化纳米石墨烯材料。可以在同一反应器中一步完成从原始石墨材料到NGPs的同时生产和功能化。
• Production process for chemically functionalized nano graphene materials
  申请人：Zhamu Aruna

  公开号：US20130001068A1

  公开（公告）日：2013-01-03

  A combined production-functionalization process for producing a chemically functionalized nano graphene material from a pre-intercalated, oxidized, or halogenated graphite material, comprising: (A) Producing exfoliated graphite from the pre-intercalated, oxidized, or halogenated graphite material, wherein the graphite material is selected from the group consisting of natural graphite, artificial graphite, highly oriented pyrolytic graphite, carbon fiber, graphite fiber, carbon nano-fiber, graphitic nano-fiber, meso-carbon micro-bead, graphitized coke, and combinations thereof; (B) Dispersing the exfoliated graphite and an azide or bi-radical compound in a liquid medium to form a suspension; (C) Subjecting the suspension to ultrasonication with ultrasonic waves of a desired intensity for a length of time sufficient to produce nano graphene platelets and to enable a chemical reaction to occur between the nano graphene platelets and the azide or bi-radical compound to produce the functionalized nano graphene material.

  一种联合生产-功能化工艺，用于从预插层、氧化或卤素化石墨材料生产化学功能化纳米石墨材料，包括：（A）从预插层、氧化或卤素化石墨材料中生产剥离的石墨，其中石墨材料选自天然石墨、人造石墨、高度定向热解石墨、碳纤维、石墨纤维、碳纳米纤维、石墨纳米纤维、介孔碳微球、石墨化焦和其组合；（B）在液体介质中分散剥离的石墨和叠氮化合物或双自由基化合物，形成悬浊液；（C）将悬浊液暴露于所需强度的超声波下超声处理一段足够的时间，以产生纳米石墨片并使纳米石墨片与叠氮化合物或双自由基化合物发生化学反应，以生产功能化的纳米石墨材料。
• Continuous graphene fibers from functionalized graphene sheets
  申请人：Nanotek Instruments, Inc.

  公开号：US10865502B2

  公开（公告）日：2020-12-15

  Provided is a graphene-based long fiber comprising chemically functionalized graphene sheets that are chemically bonded with one another having an inter-planar spacing d002 from 0.36 nm to 1.5 nm as determined by X-ray diffraction and a non-carbon element content of 0.1% to 40% by weight, wherein the functionalized graphene sheets are substantially parallel to one another and parallel to the fiber axis direction and the fiber contains no core-shell structure, have no helically arranged graphene domains, and have a length no less than 0.5 cm and a physical density from 1.5 to 2.2 g/cm3. The graphene fiber typically has a thermal conductivity from 300 to 1,600 W/mK, an electrical conductivity from 600 to 15,000 S/cm, or a tensile strength higher than 1.0 GPa.

  提供了一种石墨烯基长纤维，该纤维由化学功能化的石墨烯片组成，这些石墨烯片彼此化学键合，经 X 射线衍射测定，其平面间距 d002 为 0.36 nm 至 1.5 nm，非碳元素含量为 0.1%到40%（重量百分比），其中功能化石墨烯薄片基本上彼此平行并平行于纤维轴线方向，纤维不包含核壳结构，没有螺旋排列的石墨烯域，长度不小于0.5厘米，物理密度为1.5到2.2克/立方厘米。石墨烯纤维的热导率通常为 300-1,600 W/mK，电导率为 600-15,000 S/cm，抗拉强度高于 1.0 GPa。
• Conducting polymer composite containing ultra-low loading of graphene
  申请人：Lin Yi-jun

  公开号：US10971281B2

  公开（公告）日：2021-04-06

  A polymer matrix composite containing graphene sheets homogeneously dispersed in a polymer matrix wherein the polymer matrix composite exhibits a percolation threshold from 0.0001% to 0.1% by volume of graphene sheets to form a 3D network of interconnected graphene sheets or network of electron-conducting pathways.

  一种聚合物基复合材料，含有均匀分散在聚合物基体中的石墨烯片，其中聚合物基复合材料中石墨烯片的渗流阈值为 0.0001%至 0.1%（按体积计算），以形成相互连接的石墨烯片三维网络或电子传导通路网络。