(Z,2S)-2-hydroxyoctadec-9-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z,2S)-2-hydroxyoctadec-9-enoic acid
• 化学式: C₁₈H₃₄O₃
• 分子量: 298.5
• InChiKey: JBSOOFITVPOOSY-IBSYWUHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• USE OF 2-HYDROXYOLEIC ACID FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER IMMUNE PATHOLOGIES
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US20200330419A1

  公开（公告）日：2020-10-22

  Provided is a method of reducing autoimmunity, including reducing an amount of self-reactive B cells in a subject expressing elevated levels of an autoantibody, wherein reducing includes administering 2-hydroxyoleic acid to the subject. Also provided is a method of treatment including administering 2-hydroxyoleic acid to a subject expressing elevated levels of an auto-antibody. Also provided is a method of promoting B cell tolerance, including promoting apoptosis of self-reactive B cells in a subject, wherein promoting includes administering 2-hydoxyoleic acid to the subject.