<3-Aethoxy-phenyl>-<4-chlor-phenyl>-amin | 93044-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: <3-Aethoxy-phenyl>-<4-chlor-phenyl>-amin
• 英文别名: N-(4-chlorophenyl)-3-ethoxybenzenamine；N-(4-chlorophenyl)-3-ethoxyaniline
• CAS: 93044-52-1
• 化学式: C₁₄H₁₄ClNO
• 分子量: 247.724
• InChiKey: DFPNKSPQDQNYKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-乙氧基苯硼酸 、 对氯苯胺 在 吡啶 、 copper diacetate 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以69%的产率得到<3-Aethoxy-phenyl>-<4-chlor-phenyl>-amin
  参考文献：
  名称：

  Copper-mediated N- and O-arylations with arylboronic acids in a continuous flow microreactor: a new avenue for efficient scalability

  摘要：

  A continuous flow procedure has been elaborated for the copper(II)-mediated N- and O-arylation of a range of compounds with arylboronic acids using a commercial microreactor setup. The compounds could be continuously generated in good yields paving the way for efficient scalability. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2008.09.159

文献信息

• Copper-mediated N- and O-arylations with arylboronic acids in a continuous flow microreactor: a new avenue for efficient scalability
  作者：Brajendra K. Singh、Christian V. Stevens、Davy R.J. Acke、Virinder S. Parmar、Erik V. Van der Eycken

  DOI：10.1016/j.tetlet.2008.09.159

  日期：2009.1

  A continuous flow procedure has been elaborated for the copper(II)-mediated N- and O-arylation of a range of compounds with arylboronic acids using a commercial microreactor setup. The compounds could be continuously generated in good yields paving the way for efficient scalability. (C) 2008 Published by Elsevier Ltd.