9-氯-芴-9-羧酸甲酯 | 2314-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 9-氯-芴-9-羧酸甲酯
• 英文名称: 9-chloro-fluorene-9-carboxylic acid methyl ester
• 英文别名: 9-Chlor-fluoren-9-carbonsaeure-methylester；Diphenylen-chloressigsaeure-methylester；9-chloro-9H-fluorene-9-carboxylic acid methyl ester；9-Chlor-fluoren-carbonsaeure-(9)-methylester；Methyl 9-chloro-9H-fluorene-9-carboxylate；methyl 9-chlorofluorene-9-carboxylate
• CAS: 2314-08-1
• 化学式: C₁₅H₁₁ClO₂
• 分子量: 258.704
• InChiKey: LVJVQHBKQVHYRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  9-氯-芴-9-羧酸甲酯 在 silver nitrate 作用下， 生成 acide methoxy-9 fluorene-9 carboxylique
  参考文献：
  名称：

  Klinger, Justus Liebigs Annalen der Chemie, 1912, vol. 390, p. 374

  摘要：

  DOI：
• 作为产物：
  描述：

  芴丁酯 在 氯化亚砜 作用下， 以 甲醇 、 苯 为溶剂， 生成 9-氯-芴-9-羧酸甲酯
  参考文献：
  名称：

  Spiro-tricyclicaromatic succinimide derivatives

  摘要：

  本文披露了替代或未替代的平面三环芴或其核类似物，与含有次级酰胺的五元环螺合，并且其药用盐。这些化合物在治疗糖尿病等方面非常有用。还披露了制备这些化合物的方法；包含这些化合物的药物组合物；以及治疗方法，包括在糖尿病综合征的长期、预防性治疗中适当时给予这些化合物和组合物。

  公开号：

  US04864028A1

文献信息

• Ophthalmic wound healing with aldose reductase inhibitors
  申请人：Alcon Laboratories, Inc.

  公开号：US04717725A1

  公开（公告）日：1988-01-05

  Method of promoting healing of ocular wounds comprising the topical application of an aldose reductase inhibitor; compositions comprising such inhibitors are also disclosed.

  促进眼部伤口愈合的方法包括局部应用醛糖还原酶抑制剂；还公开了包含这些抑制剂的组合物。
• Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose
  申请人：Alcon Laboratories, Inc.

  公开号：US04537892A1

  公开（公告）日：1985-08-27

  Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.

  本文披露了取代或未取代的平面三环芴或其核类似物，与含有次级酰胺的五元环螺合，并且其药学上可接受的盐。这些化合物在糖尿病治疗中等方面是有用的。还披露了制备这种化合物的方法；包含这种化合物的药物组合物；以及治疗方法，包括在糖尿病综合症的长期、预防性治疗中适时给予这种化合物和组合物。
• Klinger, Justus Liebigs Annalen der Chemie, 1912, vol. 389, p. 250
  作者：Klinger

  DOI：——

  日期：——
• Detection and Characterization of a Transient Zwitterion, the 9-Carboxylate-9-fluorenyl Cation, and Its Conjugate Acid¹
  作者：C. S. Q. Lew、B. D. Wagner、Mark P. Angelini、E. Lee-Ruff、J. Lusztyk、L. J. Johnston

  DOI：10.1021/ja962066t

  日期：1996.1.1

  Laser flash photolysis of 9-hydroxy-9-fluorenecarboxylic acid in hexafluoro-2-propanol (HFIP) generates a transient with lambda(max) at 495 nm that reacts with nucleophiles such as methanol and bromide and is insensitive to oxygen. In the presence of 0.15 M trifluoroacetic acid, a different transient with lambda(max) at 560 nm that also reacts with nucleophiles is formed. The 495 and 560 nm species are identified as a zwitterion (the 9-carboxylate-9-fluorenyl cation) and its conjugate acid (the 9-carboxy-9-fluorenyl cation), respectively. The assignment of the zwitterion is supported by the observation of infrared absorptions in the carboxylate region that are quenched by nucleophiles with rate constants similar to those obtained by UV-visible detection. Both the zwitterion and its protonated form are observed at intermediate acid concentrations, leading to an estimate of 1 x 10(-2) M(-1) for the equilibrium constant for the ionization of the 9-carboxy-9-fluorenyl cation in HFIP. Absolute rate constants for reaction of the zwitterion with alcohols, anionic nucleophiles, and substituted aromatics are reported and compared to data for other 9-fluorenyl cations.
• Kolvenbach, Dissertation <Koenigsberg 1897>, S. 34
  作者：Kolvenbach

  DOI：——

  日期：——