thymidine-5'-monophosphate sodium | 61240-13-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: thymidine-5'-monophosphate sodium
• 英文别名: thymidine 5'-monophosphate sodium salt；thymidine monophosphate monosodium salt；Sodium ((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl hydrogen phosphate；sodium;[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate
• CAS: 61240-13-9
• 化学式: C₁₀H₁₄N₂O₈P*Na
• 分子量: 344.193
• InChiKey: PZWOWZCSLGDRQJ-HNPMAXIBSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.03
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  thymidine-5'-monophosphate sodium 在 1-(benzenesulfonyl)-3-methylimidazolium triflate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.02h， 生成 β-D-galactose-thymidine-5'-diphosphate diammonium salt
  参考文献：
  名称：

  磺酰基咪唑鎓盐作为快速高效合成核苷多磷酸盐及其缀合物的试剂

  摘要：

  描述了使用磺酰亚胺咪唑鎓盐作为关键试剂合成核苷多磷酸盐及其缀合物的方法。该方法是快速且高产率的，不需要供体或受体的事先保护和随后的脱保护，并且可以用于活化核苷单，二和三磷酸，并且可以使用各种各样的受体和供体。

  DOI：

  10.1021/ol203178k

文献信息

• MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：US20220160744A1

  公开（公告）日：2022-05-26

  The present invention relates to a multilayer pharmaceutical or nutraceutical solid dosage form comprising at least one pyrimidine derivative, purine derivative or any salt or solvate thereof and least one B-group vitamin. It also provides three methods for producing said multilayer pharmaceutical or nutraceutical solid dosage forms. Furthermore, the present invention is also related to therapeutic uses of said multilayer pharmaceutical or nutraceutical solid dosage forms, particularly for the treatment and/or prevention of peripheral neuropathy.
• [EN] MULTILAYER PHARMACEUTICAL OR NUTRACEUTICAL SOLID DOSAGE FORMS COMPRISING PYRIMIDINE AND/OR PURINE DERIVATIVES AND B VITAMINS, PREPARATION AND USES THEREOF<br/>[FR] FORMES POSOLOGIQUES SOLIDES PHARMACEUTIQUES OU NUTRACEUTIQUES MULTICOUCHES COMPRENANT DES DÉRIVÉS DE PYRIMIDINE ET/OU DE PURINE ET DES VITAMINES B, LEUR PRÉPARATION ET LEURS UTILISATIONS
  申请人：FERRER INT

  公开号：WO2020224795A1

  公开（公告）日：2020-11-12

  The present invention relates to a multilayer pharmaceutical or nutraceutical solid dosage form comprising at least one pyrimidine derivative, purine derivative or any salt or solvate thereof and least one B-group vitamin. It also provides three methods for producing said multilayer pharmaceutical or nutraceutical solid dosage forms. Furthermore, the present invention is also related to therapeutic uses of said multilayer pharmaceutical or nutraceutical solid dosage forms, particularly for the treatment and/or prevention of peripheral neuropathy.
• Sulfonyl Imidazolium Salts as Reagents for the Rapid and Efficient Synthesis of Nucleoside Polyphosphates and Their Conjugates
  作者：Samy Mohamady、Ahmed Desoky、Scott D. Taylor

  DOI：10.1021/ol203178k

  日期：2012.1.6

  A procedure for the synthesis of nucleoside polyphosphates and their conjugates using sulfonylimidazolium salts as key reagents is described. The procedure is rapid and high yielding, does not require prior protection and subsequent deprotection of the donors or acceptors, and can be used to activate nucleoside mono-, di- and triphosphates, and a wide variety of acceptors and donors can be used.

  描述了使用磺酰亚胺咪唑鎓盐作为关键试剂合成核苷多磷酸盐及其缀合物的方法。该方法是快速且高产率的，不需要供体或受体的事先保护和随后的脱保护，并且可以用于活化核苷单，二和三磷酸，并且可以使用各种各样的受体和供体。