苯基双(吡啶-2-基)甲醇 | 54467-34-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 苯基双(吡啶-2-基)甲醇
• 英文名称: phenyldi(pyridin-2-yl)methanol
• 英文别名: Di(2-pyridyl)phenylmethanol；phenyl(dipyridin-2-yl)methanol
• CAS: 54467-34-4
• 化学式: C₁₇H₁₄N₂O
• 分子量: 262.311
• InChiKey: KAJCNOUAOMFDAR-UHFFFAOYSA-N

物化性质

• 熔点：
  96.6 °C
• 沸点：
  436.6±40.0 °C(Predicted)
• 密度：
  1.210±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  苯基双(吡啶-2-基)甲醇 在 磷化氢 、 碘 作用下， 生成 dipyridylphenylmethane
  参考文献：
  名称：

  Otto et al., Recueil des Travaux Chimiques des Pays-Bas, 1959, vol. 78, p. 446,450

  摘要：

  DOI：
• 作为产物：
  描述：

  2-吡啶基锂 在 乙醚 作用下， 生成 苯基双(吡啶-2-基)甲醇
  参考文献：
  名称：

  Wibaut et al., Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 1054,1061

  摘要：

  DOI：

文献信息

• MELANIN PRODUCTION INHIBITOR
  申请人：Yokoyama Kouji

  公开号：US20110243865A1

  公开（公告）日：2011-10-06

  Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C 1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

  披露了一种黑色素生产抑制剂，它对黑色素的生产具有出色的抑制活性且高度安全。该黑色素生产抑制剂包括由通用公式（1）表示的化合物（不包括克霉唑）和/或其药理上可接受的盐。在公式中，A1、A2和A3独立地选自氢原子、可能带有取代基的芳基团和可能带有取代基的芳香杂环团，其中至少A1、A2和A3之一选自芳基团和芳香杂环团，A1、A2和A3中包含的碳原子总数为6至50，并且当至少两个A1、A2和A3表示芳基团或芳香杂环团时，相邻的两个芳基或芳香杂环团可以通过烷基链或烯基链相互连接形成环；m代表0至2的整数；X代表异原子、氢原子或碳原子；R1和R2独立地选自氢原子和氧代基，其中当R1和R2之一是氧代基时，另一个不出现；R3选自氢原子和C 1-8 碳氢化合物组，其中一些或所有的氢原子或碳原子可能被异原子或异原子取代，其中化合物中存在的R3的数量对应于X的数量，并且当存在两个或更多R3时，R3独立地存在，并且相邻的两个R3可以相互连接以与X一起形成环，并且R3的末端可以与A1、A2和A3连接的碳原子结合，从而形成环。
• Preparation of pyridyl grignard reagents and cross coupling reactions with sulfoxides bearing azaheterocycles
  作者：Naomichi Furukawa、Tadao Shibutani、Hisashi Fujihara

  DOI：10.1016/s0040-4039(01)81070-4

  日期：1987.1

  Pyridyl Grignard reagents were prepared from the corresponding iodopyridine and EtMgBr. New cross coupling reactions of the Grignard reagents with azaheterocycles took place on the sulfinyl sulfur atom to afford biazaheteroaryls.

  由相应的碘吡啶和EtMgBr制备吡啶基格氏试剂。格氏试剂与氮杂杂环的新的交叉偶联反应在亚磺酰基硫原子上发生，从而得到重氮杂芳基。
• Mechanistically Driven Control over Cubane Oxo Cluster Catalysts
  作者：Fangyuan Song、Karrar Al-Ameed、Mauro Schilling、Thomas Fox、Sandra Luber、Greta R. Patzke

  DOI：10.1021/jacs.9b01356

  日期：2019.6.5

  reaction of the key dimeric building block [M2(dpy-COH}O)2(H2O)4]2+ with monomers, such as [Co(dpy-COH}O)(OAc)(H2O)3]. Furthermore, both experiments and DFT calculations support an energetically favorable type 1 cubane formation pathway via direct head-to-head combination of two [Co2(dpy-COH}O)2(OAc)2(H2O)2] dimers. Finally, the visible-light-driven water oxidation activity of type 1 and 2 cubanes with

  对多核氧簇和相关材料的预测和机械驱动的获取仍然是无机化学的一个巨大挑战。我们在这里介绍了一种新的策略来合成控制备受追捧的过渡金属 M4O4} 古巴。它们作为分子水氧化催化剂引起了人们的兴趣，它结合了非均相氧化物催化剂和自然光系统 II 的立方体 CaMn4O5} 中心的特征。我们首次证明了溶液中直接无机抗衡阴离子对氧簇自组装的出色结构导向作用。我们引入了选择性反阴离子工具箱，用于将二（2-吡啶基）酮（dpk）与 M（OAc）2（M = Co，Ni）前体受控组装成不同的立方烷类型。高氯酸根阴离子提供对具有特征 H2O-M2(OR)2-OH2} 边缘位点的 2 型立方烷的选择性访问，例如 [Co4(dpy-COH}O)4(OAc)2(H2O)2] (ClO4)2。具有分离极性面的 1 型立方烷 [Co4(dpy-COH}O)4(L2)4] n+（L2 = OAc、Cl 或 OAc 和
• Melanin production inhibitor
  申请人：Yokoyama Kouji

  公开号：US08846012B2

  公开（公告）日：2014-09-30

  Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent. At least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group. When one of R1 and R2 is an oxo group, the other is not present. R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

  本发明涉及一种黑色素生成抑制剂，其在抑制黑色素生成方面具有优异的抑制活性，并且非常安全。该黑色素生成抑制剂由通式（1）（不包括克霉唑）和/或其药理学上可接受的盐所表示。在该式中，A1、A2和A3独立地选自氢原子、可能具有取代基的芳基基团和可能具有取代基的芳香杂环基团。A1、A2和A3中至少有一个选自芳基基团和芳香杂环基团，A1、A2和A3所含的碳原子总数为6到50，当A1、A2和A3中至少有两个表示芳基或芳香杂环基团时，相邻的两个芳基或芳香杂环基团可以通过烷基链或烯基链相互结合形成环；m表示0到2的整数；X表示杂原子、氢原子或碳原子；R1和R2独立地选自氢原子和氧代基团。当R1和R2中的一个是氧代基团时，另一个不存在。R3选自氢原子和C1-8烃基，其中一些氢原子或碳原子可能被杂原子或杂原子取代。化合物中R3的数量对应于X，当存在两个或更多的R3时，R3独立存在，相邻的两个R3可以相互结合形成与X一起的环，R3的末端可以与A1、A2和A3结合的碳原子结合，从而形成一个环。
• Mn₇ Species with an <i>S</i> = ²⁹/₂ Ground State: High-Frequency EPR Studies of a Species at the Classical/Quantum Spin Interface
  作者：Zhenxing Wang、Johan van Tol、Taketo Taguchi、Matthew R. Daniels、George Christou、Naresh S. Dalal

  DOI：10.1021/ja207636b

  日期：2011.11.9

  straddle the interface between the classical and quantum mechanical spin descriptions. The cluster [Mn(7)O(4)(pdpm)(6)(N(3))(4)](ClO(4))(2) (Mn(7)) has an unprecedented core structure comprising an octahedral [Mn(III)(6)(μ(4)-O)(μ(3)-O)(3)(μ(3)-N(3))(4)](6+) unit with one of its faces capped by a Mn(II) ion. Magnetization and susceptibility studies indicate an S = (29/2) ground state, the maximum possible

  已经合成了一种高自旋 (S) 化合物，其性质跨越了经典和量子力学自旋描述之间的界面。簇 [Mn(7)O(4)(pdpm)(6)(N(3))(4)](ClO(4))(2) (Mn(7)) 具有前所未有的核心结构，包括八面体[Mn(III)(6)(μ(4)-O)(μ(3)-O)(3)(μ(3)-N(3))(4)](6+) 单元与其中之一它的表面被 Mn(II) 离子覆盖。磁化和磁化率研究表明 S = (29/2) 基态，这是可能的最大值。Mn(7) 粉末和单晶样品的变温、高频电子顺磁共振 (HF-EPR) 光谱表现出量子自旋的尖锐光谱特征，在特定温度范围内可以很好地分辨，但会转变为另一个经典自旋的连续峰特征；这些特征已被计算机模拟很好地再现。对尖锐光谱特征和低温 EPR 光谱的快速傅立叶变换分析表明，涉及不止一种自旋状态。