N-benzyl-2-(N-benzylacetamido)-2-(2-bromophenyl)acetamide | 1437799-11-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-benzyl-2-(N-benzylacetamido)-2-(2-bromophenyl)acetamide
• 英文别名: 2-[acetyl(benzyl)amino]-N-benzyl-2-(2-bromophenyl)acetamide
• CAS: 1437799-11-5
• 化学式: C₂₄H₂₃BrN₂O₂
• 分子量: 451.363
• InChiKey: YIDLEBQPHVIVLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴苄醇 在 2-碘酰基苯甲酸 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 41.0h， 生成 N-benzyl-2-(N-benzylacetamido)-2-(2-bromophenyl)acetamide
  参考文献：
  名称：

  Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences

  摘要：

  A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of primary alcohols were oxidized to the aldehyde that were directly engaged in the Ugi four-component reaction to afford alpha-acetamidoamides in good to excellent yields.

  DOI：

  10.1021/ol401181a

文献信息

• Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences
  作者：Fleur Drouet、Géraldine Masson、Jieping Zhu

  DOI：10.1021/ol401181a

  日期：2013.6.7

  A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of primary alcohols were oxidized to the aldehyde that were directly engaged in the Ugi four-component reaction to afford alpha-acetamidoamides in good to excellent yields.