2-[4-(Aminomethyl)anilino]-2-oxoacetic acid | 840454-25-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(Aminomethyl)anilino]-2-oxoacetic acid
• CAS: 840454-25-3
• 化学式: C₉H₁₀N₂O₃
• 分子量: 194.19
• InChiKey: RKILOCCSAVHHJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Novel N-aryl Oxamic Acids
  申请人：Purdue Research Foundation

  公开号：US20210309606A1

  公开（公告）日：2021-10-07

  The present disclosure relates to novel N-aryl oxamic acid based inhibitors for Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB), and to the method of making and using the novel N-aryl oxamic acid based inhibitors. More specifically, compounds provided in this disclosure can be used to inhibit Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) and to treat a patient having a Tuberculosis disease.

  本公开涉及新型N-芳基羟酰胺酸基抑制剂，用于结核分枝杆菌蛋白酪氨酸磷酸酶B（mPTPB），以及制备和使用这种新型N-芳基羟酰胺酸基抑制剂的方法。更具体地说，本公开提供的化合物可用于抑制结核分枝杆菌蛋白酪氨酸磷酸酶B（mPTPB），并用于治疗患有结核病的患者。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• N-aryl oxamic acids
  申请人：Purdue Research Foundation

  公开号：US11192850B2

  公开（公告）日：2021-12-07

  The present disclosure relates to novel N-aryl oxamic acid based inhibitors for Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB), and to the method of making and using the novel N-aryl oxamic acid based inhibitors. More specifically, compounds provided in this disclosure can be used to inhibit Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) and to treat a patient having a Tuberculosis disease.

  本公开涉及新型N-芳基氨基甲酸基结核分枝杆菌蛋白酪氨酸磷酸酶B（mPTPB）抑制剂，以及新型N-芳基氨基甲酸基抑制剂的制造和使用方法。更具体地说，本公开提供的化合物可用于抑制结核分枝杆菌蛋白酪氨酸磷酸酶 B (mPTPB)和治疗结核病患者。
• ADVANCED DRUG DEVELOPMENT AND MANUFACTURING
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519A2

  公开（公告）日：2009-08-05
• X-RAY FLUORESCENCE ANALYSIS METHOD
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519B1

  公开（公告）日：2012-08-01