7-phenyl-2-phenylamino-6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-one | 1034738-52-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-phenyl-2-phenylamino-6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-one
• 英文别名: 7-Phenyl-2-(phenylamino)-4H,6H,7H-[1,3]thiazolo[4,5-b]pyridin-5-one；2-anilino-7-phenyl-6,7-dihydro-4H-[1,3]thiazolo[4,5-b]pyridin-5-one
• CAS: 1034738-52-7
• 化学式: C₁₈H₁₅N₃OS
• 分子量: 321.403
• InChiKey: LAINAZUYFAUXLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  82.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 、 苯甲醛 以 乙醇 、 溶剂黄146 为溶剂， 反应 2.0h， 以67%的产率得到7-phenyl-2-phenylamino-6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-one
  参考文献：
  名称：

  Three-component condensation of 2,4-diaminothiazoles with aldehydes and Meldrum's acid: synthesis of 7-aryl(alkyl)-substituted 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones

  摘要：

  The new method of the synthesis of 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones, based on decarboxylation of corresponding 2,4-diamino-5-thiazolecarboxylic acids has been elaborated; unstable derivatives of 2,4-diaminothiazole, generated in situ as a result of decarboxylation, react with aldehydes and Meldrum's acid forming target compounds.

  DOI：

  10.1016/j.mencom.2009.03.011

文献信息

• Three-component condensation of 2,4-diaminothiazoles with aldehydes and Meldrum's acid: synthesis of 7-aryl(alkyl)-substituted 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones
  作者：Arkady A. Dudinov、Boris V. Lichitsky、Andrey N. Komogortsev、Mikhail M. Krayushkin

  DOI：10.1016/j.mencom.2009.03.011

  日期：2009.3

  The new method of the synthesis of 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones, based on decarboxylation of corresponding 2,4-diamino-5-thiazolecarboxylic acids has been elaborated; unstable derivatives of 2,4-diaminothiazole, generated in situ as a result of decarboxylation, react with aldehydes and Meldrum's acid forming target compounds.