申请人:Collegium Pharmaceutical, Inc.
公开号:EP2108360A2
公开(公告)日:2009-10-14
A stable topical alcohol-free aerosol foam containing one or more keratolytic agents is provided. The foam-forming formulation is an emulsion which contains an HFA propellant and one or more keratolytic agents. The emulsion has an oil phase and an aqueous, i.e. water-containing, phase. The active agent(s) may be present in either phase of the emulsion or dispersed in the emulsion. The oil phase may consist at least in part of the HFA propellant. Either or both of the oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and/or other excipients. The foam is stable on the skin, for example, for at least 5 minutes at body temperature, preferably at least 20 minutes at body temperature, and disappears into the skin upon rubbing or after prolonged standing. In one embodiment, the formulation contains an HFA propellant which does not contain additional co-solvents or co-propellants. The formulations demonstrate reduced intensity of the odor and/or color associated with the keratolytic agent(s) as compared to conventional formulations containing keratolytic agents.
提供了一种含有一种或多种角质溶解剂的稳定的局部无醇气溶胶泡沫。泡沫形成配方是一种乳液,含有氢氟烷烃推进剂和一种或多种角质溶解剂。乳液具有油相和水相,即含水相。活性剂可以存在于乳液的任一相中,也可以分散在乳液中。油相至少可以由部分氢氟烷烃推进剂组成。油相和水相的任一相或两相可含有一种或多种表面活性剂、乳化剂、乳液稳定剂、缓冲剂和/或其他赋形剂。泡沫在皮肤上是稳定的,例如在体温下至少可持续 5 分钟,最好在体温下至少可持续 20 分钟,并且在摩擦皮肤或长时间站立后会消失在皮肤中。在一个实施方案中,配方含有一种不含额外助溶剂或助推进剂的氢氟烷烃推进剂。与含有角质溶解剂的传统配方相比,这些配方显示出与角质溶解剂相关的气味和/或颜色强度降低。