6-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]hexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 6-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]hexanoic acid
• 英文别名: 6-[6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoylamino]hexanoic acid
• 化学式: C₅₃H₅₀N₃O₅PolS
• 分子量: 466.6
• InChiKey: OFWLGDBIGLPFNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]hexanoic acid 在 三异丙基硅烷 、 三氟乙酸 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues

  摘要：

  Here we identify the pharmacophore in a peptoid that antagonizes Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) in vitro and in vivo. Only three of the side chains in the peptoid are required for activity. Surprisingly, however, main chain atoms also form critical interactions with the receptor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.023
• 作为产物：
  描述：

  6-氨基己酸 、 芴甲氧羰酰基-6-氨基己酸 在 N-甲基吗啉 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 作用下， 生成 6-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]hexanoic acid
  参考文献：
  名称：

  The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues

  摘要：

  Here we identify the pharmacophore in a peptoid that antagonizes Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) in vitro and in vivo. Only three of the side chains in the peptoid are required for activity. Surprisingly, however, main chain atoms also form critical interactions with the receptor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.023

文献信息

• Oligonucleotide-polyamide conjugates
  申请人：HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE

  公开号：EP0972779A2

  公开（公告）日：2000-01-19

  Oligonucleotide-polyamide conjugates of the formula X-L-Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

  式 X-L-Y 的寡核苷酸-聚酰胺共轭物，其中 X 是聚酰胺，Y 是寡核苷酸，L 是连接体，它与聚酰胺 X 的氨基末端和寡核苷酸 Y 的 3'磷酸基团形成共价键。可通过在固体支持基质上组装聚酰胺，加入合适的连接分子，然后合成寡核苷酸来合成共轭物。还介绍了用寡核苷酸-聚酰胺共轭物检测特定多核苷酸的方法。
• OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES
  申请人：HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE

  公开号：EP0383803B1

  公开（公告）日：2000-05-03
• EP0383803A4
  申请人：——

  公开号：EP0383803A4

  公开（公告）日：1991-03-20
• PSORALEN CONJUGATED METHYLPHOSPHONATE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS FOR CHRONIC MYELOGENOUS LEUKEMIA
  申请人：GENTA INCORPORATED

  公开号：EP0542887A1

  公开（公告）日：1993-05-26
• US5525465A
  申请人：——

  公开号：US5525465A

  公开（公告）日：1996-06-11