苯基甲基N-[(2S)-5-(二氨基亚甲基氨基)-1-[[(2S)-5-(二氨基亚甲基氨基)-1-(萘-2-基氨基)-1-氧代戊烷-2-基]氨基]-1-氧代戊烷-2-基]氨基甲酸酯 | 76474-52-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苯基甲基N-[(2S)-5-(二氨基亚甲基氨基)-1-[[(2S)-5-(二氨基亚甲基氨基)-1-(萘-2-基氨基)-1-氧代戊烷-2-基]氨基]-1-氧代戊烷-2-基]氨基甲酸酯
• 英文名称: N-Benzyloxycarbonylarginyl-L-arginine-2-naphthylamide
• 英文别名: benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-(naphthalen-2-ylamino)-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
• CAS: 76474-52-7
• 化学式: C₃₀H₃₉N₉O₄
• 分子量: 589.7
• InChiKey: QOCSAYREMKOPJF-DQEYMECFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  43
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  225
• 氢给体数：
  7
• 氢受体数：
  6

文献信息

• Functional MRI agents for cancer imaging
  申请人：——

  公开号：US20040146463A1

  公开（公告）日：2004-07-29

  The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.

  本发明涉及用于癌症成像的新型磁共振成像对比剂。
• Reagent for testing periodontal diseases
  申请人：SUNSTAR KABUSHIKI KAISHA

  公开号：EP0255341A2

  公开（公告）日：1988-02-03

  A reagent for testing periodontal diseases which diagnoses or prognosticates contraction or progress of said diseases by determining aminopeptidase-like enzymatic activity in a specimen, said reagent comprises as a substrate for the enzyme either or both compounds of the formula: X-Z-Arg-Y [1] wherein Arg is arginine residue; X is hydrogen or an amino blocking group; Y is a color developing group attached to the C-terminal of Arg; and Z is an amino acid or peptide residue composed of 1 to 4 amino acids or their blocked derivatives, the C-terminal of which is attached to the N-­terminal of Arg, and Xʹ-Zʹ-Pro-Yʹ [2] wherein Pro is proline residue; Xʹ is hydrogen or an amino blocking group; Yʹ is a color developing group attached to the C-terminal of Pro; and Zʹ is an amino acid or peptide residue composed of 0 to 4 amino acids or their blocked derivatives, the C-terminal of which is attached to the N-­terminal of Pro.

  一种检测牙周疾病的试剂，它通过测定标本中氨基肽酶样酶的活性来诊断或预测所述疾病的收缩或进展，所述试剂包括作为酶底物的式中的一种或两种化合物： X-Z-Arg-Y [1] 其中 Arg 是精氨酸残基；X 是氢或氨基封端基；Y 是连接到 Arg C 端的显色基团；Z 是由 1 至 4 个氨基酸或其封端衍生物组成的氨基酸或肽残基，其 C 端连接到 Arg 的 N 端，以及 Xʹ-Zʹ-Pro-Yʹ[2］ 其中Pro是脯氨酸残基；Xʹ是氢或氨基封端基；Yʹ是连接到Pro的C-末端的显色基团；Zʹ是由0至4个氨基酸或其封端衍生物组成的氨基酸或肽残基，其C-末端连接到Pro的N-末端。
• Novel functional agents for magnetic resonance imaging
  申请人：——

  公开号：US20030021750A1

  公开（公告）日：2003-01-30

  The present invention is directed to non-macrocyclic functional MRI contrast agents that can be used to detect the presence of physiological target substances.

  本发明涉及可用于检测生理目标物质存在的非大环功能性磁共振成像造影剂。
• Multifunctional photodynamic agents for treating of disease
  申请人：MPA Technologies, Inc.

  公开号：US20040247527A1

  公开（公告）日：2004-12-09

  The present invention is directed to methods and compositions comprising multifunctional (usually bi- or tri-functional) agents that incorporate a targeting moiety, a photo dynamic therapy (PDT) moiety (either one or two photon), and an optional imaging agent (such as a chromophore, contrast agent, etc.).

  本发明涉及包含多功能（通常是双功能或三功能）制剂的方法和组合物，这些制剂包含靶向分子、光动力疗法（PDT）分子（单光子或双光子）和任选成像剂（如发色团、造影剂等）。
• FUNCTIONAL MRI AGENTS FOR CANCER IMAGING
  申请人：RESEARCH CORPORATION TECHNOLOGIES

  公开号：EP1278552A2

  公开（公告）日：2003-01-29