E-2-hydroxyoct-4-enoic acid | 90113-62-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: E-2-hydroxyoct-4-enoic acid
• 英文别名: 2-hydroxy-4-octenoic acid；(E)-2-hydroxyoct-4-enoic acid
• CAS: 90113-62-5；90701-41-0
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: VFWGSPRMACOKLS-SNAWJCMRSA-N

物化性质

• 沸点：
  305.7±22.0 °C(Predicted)
• 密度：
  1.078±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  E-1,1,1-trichloro-oct-4-en-2-ol 在 sodium hydroxide 、 苄基三乙基氯化铵 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 6.0h， 以35%的产率得到E-2-hydroxyoct-4-enoic acid
  参考文献：
  名称：

  Benner, Jill P.; Gill, G. Bryon; Parrott, Stephen J., Journal of the Chemical Society. Perkin transactions I, 1984, # 3, p. 331 - 342

  摘要：

  DOI：

文献信息

• Cosmetic composition comprising 2-hydroxyalkenoic acids or a mixture
  申请人：Chesebrough-Pond's USA Co., Division of Conopco, Inc.

  公开号：US05108751A1

  公开（公告）日：1992-04-28

  The invention concerns 2-hydroxyalkenoic acids within a general formula ##STR1## where R' is chosen from: a. C.sub.w H.sub.2w, b. C.sub.y H.sub.2y-1, and c. C.sub.y H.sub.2y OZ where z is chosen from H, R" and (CH.sub.2).sub.n OR" R" is chosen from C.sub.m H.sub.2m+1 and (CH.sub.2).sub.n OC.sub.m H.sub.2m+1 ; w is an integer of from 1 to 25 y is an integer of from 2 to 25 m is an integer of from 1 to 4 n is an integer of from 1 to 6 Many compounds within the formula are novel and are claimed as such. The invention also provides a process for making the compounds, and compositions for topical application to human skin, hair or nails which contain compounds of the above formula and a cosmetically acceptable vehicle.

  该发明涉及一般公式为##STR1##的2-羟基烯酸，其中R'选择自：a. C.sub.w H.sub.2w, b. C.sub.y H.sub.2y-1, 和 c. C.sub.y H.sub.2y OZ，其中z选择自H、R"和(CH.sub.2).sub.n OR"，R"选择自C.sub.m H.sub.2m+1 和 (CH.sub.2).sub.n OC.sub.m H.sub.2m+1；w为从1到25的整数，y为从2到25的整数，m为从1到4的整数，n为从1到6的整数。该公式中的许多化合物是新颖的，并作为这样声称。该发明还提供了制备这些化合物的方法，以及含有上述公式化合物和化妆学上可接受的载体的用于局部涂抹于人体皮肤、头发或指甲的组合物。
• Cosmetic composition containing alpha hydroxy carboxylic acids as preservatives
  申请人：UNILEVER PLC

  公开号：EP0568307A1

  公开（公告）日：1993-11-03

  The use of at least 0.0001% by weight based on the total composition of an hydroxy organic acid having the structure (1): where    R is chosen from CxHy and CxHyOZ,    x is an integer of from 2 to 16,    y is an integer of from 5 to 53,    Z is chosen from -H,R' and (CH₂)n OR',    R' is chosen from CaHb and (CH₂)n OCaHb,    a is an integer of from 1 to 4,    b is an integer of from 2 to 9,    n is an integer of from 1 to 6. and mixtures thereof; as an inhibitor of microbial spoilage, together with a major amount of a cosmetically acceptable vehicle, in a composition intended for topical application to the human body.

  至少按照总成分重量的0.0001%使用具有结构（1）的羟基有机酸，其中：其中R选择自CₓHᵧ和CₓHᵧOZ，x为2至16的整数，y为5至53的整数，Z选择自-H、R'和（CH₂）n OR'，R'选择自CₐHᵇ和（CH₂）n OCaHᵇ，a为1至4的整数，b为2至9的整数，n为1至6的整数，以及它们的混合物；作为微生物腐败抑制剂，与大量的符合化妆标准的载体一起，在用于局部涂抹到人体的组合物中。
• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0442708A2

  公开（公告）日：1991-08-21

  The invention concerns 2-hydroxyalkenoic acids within a general formula where R′ is chosen from: a. CwH2w+1 b. CyH2y₋₁, and c. CyH2yOZ    where Z is chosen from H, R˝ and (CH₂)nOR˝       R˝ is chosen from CmH2m+1 and (CH₂)nOCmH2m+1;       w is an integer of from 1 to 25       y is an integer of from 2 to 25       m is an integer of from 1 to 4       n is an integer of from 1 to 6 Many compounds within the formula are novel and are claimed as such. The invention also provides a process for making the compounds, and compositions for topical application to human skin, hair or nails which contain compounds of the above formula and a cosmetically acceptable vehicle.

  本发明涉及通式如下的 2-羟基烯酸 其中R′选自 a.CwH2w+1 b.CyH2y₋₁, 和 c.CyH2yOZ 其中 Z 选自 H、R˝ 和 (CH₂)nOR˝ R˝ 选自 CmH2m+1 和 (CH₂)nOCmH2m+1； w 是 1 到 25 之间的整数 y 是 2 至 25 之间的整数 m 是 1 至 4 的整数 n 是 1 至 6 的整数 式中的许多化合物都是新颖的，因此提出权利要求。本发明还提供了一种制造上述化合物的工艺，以及用于人体皮肤、头发或指甲局部涂抹的组合物，该组合物含有上式化合物和一种化妆品可接受的载体。
• SYNERGISTIC PRESERVATIVE COMPOSITIONS
  申请人：ISP Investments LLC

  公开号：EP3288380A1

  公开（公告）日：2018-03-07
• SYNERGISTIC PRESERVATIVE COMPOSITIONS, PROCESS FOR PREPARING THE SAME AND METHOD OF USE THEREOF
  申请人：ISP Investments LLC

  公开号：EP3886582A1

  公开（公告）日：2021-10-06