5-Methyl-3-(2-pyridyl)isoxazol | 85903-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Methyl-3-(2-pyridyl)isoxazol
• 英文别名: 2-(5-methyl-isoxazol-3-yl)-pyridine；2-(5-Methyl-isoxazol-3-yl)-pyridin；5-Methyl-3-(pyridin-2-yl)isoxazole；5-methyl-3-pyridin-2-yl-1,2-oxazole
• CAS: 85903-31-7
• 化学式: C₉H₈N₂O
• 分子量: 160.175
• InChiKey: AEWOSLUFNXTPSI-UHFFFAOYSA-N

物化性质

• 熔点：
  41-42 °C (sublm)
• 沸点：
  298.2±25.0 °C(Predicted)
• 密度：
  1.142±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  溶剂黄146 、 alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 5-Methyl-3-(2-pyridyl)isoxazol
  参考文献：
  名称：

  Micko, Monatshefte fur Chemie, 1896, vol. 17, p. 451

  摘要：

  DOI：

文献信息

• Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
  申请人：Collins James Ian

  公开号：US20080070895A1

  公开（公告）日：2008-03-20

  Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

  公开了式子I的化合物：其中X是5-成员的杂环芳基环，R如此定义。这些化合物是γ-分泌酶处理APP的抑制剂，因此在治疗或预防阿尔茨海默病方面是有用的。
• BELGODERE, E.;BOSSIO, R.;SIO, F.;MARCACCINI, S.;PEPINO, R., HETEROCYCLES, 1983, 20, N 3, 501-504
  作者：BELGODERE, E.、BOSSIO, R.、SIO, F.、MARCACCINI, S.、PEPINO, R.

  DOI：——

  日期：——
• ISOXAZOLE-ISOXAZOLE AND ISOXAZOLE-ISOTHIAZOLE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2398782A1

  公开（公告）日：2011-12-28
• 6-11 Bicyclic Ketolide Derivatives
  申请人：Or Yat Sun

  公开号：US20070244160A1

  公开（公告）日：2007-10-18

  The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
• Sulphamides for Treatment of Cancer
  申请人：Lewis Huw David

  公开号：US20090197904A1

  公开（公告）日：2009-08-06

  Bridged bicyclic sulphamides of formula (I) are disclosed for treatment of cancer.