Ala-Asp | 3481-29-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ala-Asp
• 英文别名: N-alanyl-aspartic acid；N-Alanyl-asparaginsaeure；Alanylaspartic acid；2-(2-aminopropanoylamino)butanedioic acid
• CAS: 3481-29-6
• 化学式: C₇H₁₂N₂O₅
• 分子量: 204.183
• InChiKey: XAEWTDMGFGHWFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-alanyl-aspartic acid dimethyl ester 在 sodium hydroxide 作用下， 生成 Ala-Asp
  参考文献：
  名称：

  Havestadt; Fricke, Chemische Berichte, 1924, vol. 57, p. 2050

  摘要：

  DOI：

文献信息

• SOLOMONAMIDE ANALOGUE COMPOUNDS, PHARMACEUTICALS CONTAINING SOLOMONAMIDE ANALOGUE COMPOUNDS, AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20150291659A1

  公开（公告）日：2015-10-15

  Solomanamide analogues of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogues, including the synthesis of macrocyclic core of Salomanamide analogues. The Solomanamide analogues of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

  公式I的Solomanamide类似物具有抗炎活性，并且具有制备这种类似物的可行合成路线，包括制备Salomanamide类似物的大环核心的合成。公式I的Solomanamide类似物或其药物盐可以在药物组合物中提供，并以有效剂量用于治疗炎症和/或疼痛。
• Small molecule Ras inhibitors
  申请人：Briesewitz Roger

  公开号：US10736932B2

  公开（公告）日：2020-08-11

  Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. In another aspect, provided is an antibody-drug-conjugate comprising an antibody conjugated with a compound described herein. In still another aspect, provided is a pharmaceutical composition comprising a compound or antibody-drug-conjugate described herein. In a further aspect, provided is method of treating a cancer comprising administering a therapeutically effective amount of a compound or antibody-drug-conjugate described herein to a patient in need thereof.

  本文公开了作为 Ras 抑制剂的新型化合物。还公开了包含这些化合物的组合物以及使用这些化合物治疗各种疾病的方法。在另一个方面，提供了一种抗体-药物-结合物，其包含与本文所述化合物共轭的抗体。还有一方面，提供了一种药物组合物，包含本文所述的化合物或抗体-药物-轭合物。在另一个方面，提供了治疗癌症的方法，包括向有需要的患者施用治疗有效量的本文所述化合物或抗体-药物-结合物。
• A PROCESS FOR THE PREPARATION OF SOLOMONAMIDE ANALOGUES
  申请人：Council of Scientific & Industrial Research

  公开号：EP2925771A1

  公开（公告）日：2015-10-07
• SMALL MOLECULE RAC OR RHO INHIBITORS
  申请人：Ohio State Innovation Foundation

  公开号：US20170112896A1

  公开（公告）日：2017-04-27

  Disclosed herein are methods of inhibiting Rac or Rho in a cell or tissue or for treating a disease mediated at least in part by Rac or Rho, using a compound of the formula:
• SMALL MOLECULE RAS INHIBITORS
  申请人：Briesewitz Roger

  公开号：US20170304383A1

  公开（公告）日：2017-10-26

  Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. In another aspect, provided is an antibody-drug-conjugate comprising an antibody conjugated with a compound described herein. In still another aspect, provided is a pharmaceutical composition comprising a compound or antibody-drug-conjugate described herein. In a further aspect, provided is method of treating a cancer comprising administering a therapeutically effective amount of a compound or antibody-drug-conjugate described herein to a patient in need thereof.