N-nonylbutanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-nonylbutanamide
• 化学式: C₁₃H₂₇NO
• 分子量: 213.36
• InChiKey: GMDNLRZEDUUPBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• COMPOSITIONS AND METHODS FOR MODULATION OF TARGET NUCLEIC ACIDS
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：EP3564374A1

  公开（公告）日：2019-11-06

  The present disclosure pertains generally to chemically-modified oligonucleotides for use in research, diagnostics, and/or therapeutics. In certain embodiments, the present disclosure describes compounds and methods for the modulation of a target nucleic acid. In certain embodiments, the present disclosure describes compounds and methods for the modulation of Apoliprotein C-III expression.

  本公开内容一般涉及用于研究、诊断和/或治疗的化学修饰寡核苷酸。在某些实施方案中，本公开内容描述了用于调节靶核酸的化合物和方法。在某些实施方案中，本公开内容描述了用于调节载脂蛋白 C-III 表达的化合物和方法。
• COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：EP3690049A1

  公开（公告）日：2020-08-05

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoCIII). In certain embodiments, the ApoCIII targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoCIII for use in decreasing ApoCIII to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoCIII. Certain diseases, disorders or conditions related to ApoCIII include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.

  本文提供的是具有针对载脂蛋白 C-III（ApoCIII）的共轭基团的低聚化合物。在某些实施方案中，载脂蛋白 CIII 靶向低聚物化合物与 N-乙酰半乳糖胺共轭。本文还公开了用于减少载脂蛋白CIII以治疗、预防或改善与载脂蛋白CIII有关的疾病、失调或状况的靶向载脂蛋白CIII的共轭低聚物化合物。与载脂蛋白 CIII 有关的某些疾病、失调或病症包括炎症、心血管和/或代谢性疾病、失调或病症。本文公开的共轭低聚物化合物可用于治疗有需要的个体的此类疾病、失调或病症。
• Amine-containing lipids and uses thereof
  申请人：Anderson Daniel G.

  公开号：US20110009641A1

  公开（公告）日：2011-01-13

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• MODULATION OF THE IMMUNE RESPONSE
  申请人：Nguyen David-Huy Nhu

  公开号：US20120009222A1

  公开（公告）日：2012-01-12

  The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.