2-Chloro-6-methoxy-5-nitro-pyrimidin-4-ylamine

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 2-Chloro-6-methoxy-5-nitro-pyrimidin-4-ylamine
• 英文别名: 4-Amino-2-chloro-5-nitro-6-methoxypyrimidine；2-chloro-6-methoxy-5-nitropyrimidin-4-amine
• 化学式: C₅H₅ClN₄O₃
• mdl: MFCD03001375
• 分子量: 204.573
• InChiKey: PFQFMTDRIFQRSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  苯硼酸 、 2-Chloro-6-methoxy-5-nitro-pyrimidin-4-ylamine 在 palladium diacetate 、 potassium phosphate 、 1,1'-bis(di-tertbutylphosphino)ferrocene 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以82%的产率得到6-Methoxy-5-nitro-2-phenyl-pyrimidin-4-ylamine
  参考文献：
  名称：

  Direct synthesis of hetero-biaryl compounds containing an unprotected NH2 group via Suzuki–Miyaura reaction

  摘要：

  Hetero-biaryl compounds were prepared via the Suzuki-Miyaura coupling reaction of hetero-aryl moieties containing an unprotected NH2 group and arylboronic acids. D-t-BPF was found to be an efficient ligand for the cross-coupling of NH2-unprotected hetero-aryl chlorides with phenylboronic acid. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.03.053

文献信息

• Direct synthesis of hetero-biaryl compounds containing an unprotected NH2 group via Suzuki–Miyaura reaction
  作者：Takahiro Itoh、Toshiaki Mase

  DOI：10.1016/j.tetlet.2005.03.053

  日期：2005.5

  Hetero-biaryl compounds were prepared via the Suzuki-Miyaura coupling reaction of hetero-aryl moieties containing an unprotected NH2 group and arylboronic acids. D-t-BPF was found to be an efficient ligand for the cross-coupling of NH2-unprotected hetero-aryl chlorides with phenylboronic acid. (c) 2005 Elsevier Ltd. All rights reserved.